HCSGD entry for ZNF148
1. General information
| Official gene symbol | ZNF148 |
|---|---|
| Entrez ID | 7707 |
| Gene full name | zinc finger protein 148 |
| Other gene symbols | BERF-1 BFCOL1 HT-BETA ZBP-89 ZFP148 pHZ-52 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0000976 | Transcription regulatory region sequence-specific DNA binding | IEA | molecular_function |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003690 | Double-stranded DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006461 | Protein complex assembly | IEA | biological_process |
| GO:0006968 | Cellular defense response | TAS | biological_process |
| GO:0007276 | Gamete generation | IEA | biological_process |
| GO:0010629 | Negative regulation of gene expression | IDA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IDA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9337037119 | 0.0309053493 | 0.9999902473 | 0.3311875101 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3668222001 |
| GSE13712_SHEAR | Down | -0.0379242156 |
| GSE13712_STATIC | Down | -0.0856259124 |
| GSE19018 | Up | 0.0206237597 |
| GSE19899_A1 | Down | -0.3287073634 |
| GSE19899_A2 | Down | -0.2589799764 |
| PubMed_21979375_A1 | Down | -0.8892062552 |
| PubMed_21979375_A2 | Down | -0.5344480081 |
| GSE35957 | Up | 0.2662332582 |
| GSE36640 | Up | 0.1016376658 |
| GSE54402 | Down | -0.3489199210 |
| GSE9593 | Up | 0.0404486909 |
| GSE43922 | Down | -0.3318298874 |
| GSE24585 | Up | 0.1120015724 |
| GSE37065 | Up | 0.1342258136 |
| GSE28863_A1 | Down | -0.1547134745 |
| GSE28863_A2 | Up | 0.2230124585 |
| GSE28863_A3 | Down | -0.7788780699 |
| GSE28863_A4 | Down | -0.4000328881 |
| GSE48662 | Up | 0.3116912348 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-203a | MIMAT0000264 | MIRT006269 | Luciferase reporter assay | Functional MTI | 22354972 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018719 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021205 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT021856 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025207 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028179 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-425-5p | MIMAT0003393 | MIRT039326 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051980 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19583777 | The transcription factor ZBP-89 suppresses p16 expression through a histone modification mechanism to affect cell senescence |
| 19583777 | The transcription factor ZBP-89 has been implicated in the induction of growth arrest and apoptosis |
| 19583777 | In this article, we demonstrate that ZBP-89 was able to restrain senescence in NCI-H460 human lung cancer cells, through epigenetically regulating p(16INK4a) expression |
| 19583777 | Specifically, our results indicate that knockdown of ZBP-89 by RNA interference stimulated cellular senescence in NCI-H460 cells, as judged by the senescence-associated beta-galactosidase activity assay and senescence-associated heterochromatin foci assay, and this process could be reversed by RNA interference-mediated p16(INK4a) silencing |
| 19583777 | Furthermore, chromatin immunoprecipitation assays verified that HDAC3 was recruited to the p16(INK4a) promoter by ZBP-89 through an epigenetic mechanism involving histone acetylation modification |
| 19583777 | Moreover, immunofluorescence and coimmunoprecipitation assays revealed that ZBP-89 and HDAC3 formed a complex |
| 19583777 | These data suggest that ZBP-89 and HDAC3, but not HDAC4, can work coordinately to restrain cell senescence by downregulating p16(INK4a) expression through an epigenetic modification of histones |
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