HCSGD entry for PCGF2
1. General information
| Official gene symbol | PCGF2 |
|---|---|
| Entrez ID | 7703 |
| Gene full name | polycomb group ring finger 2 |
| Other gene symbols | MEL-18 RNF110 ZNF144 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IMP | biological_process |
| GO:0000790 | Nuclear chromatin | IDA | cellular_component |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001739 | Sex chromatin | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0009952 | Anterior/posterior pattern specification | IEA | biological_process |
| GO:0016573 | Histone acetylation | IEA | biological_process |
| GO:0016604 | Nuclear body | IEA | cellular_component |
| GO:0031519 | PcG protein complex | IDA | cellular_component |
| GO:0035102 | PRC1 complex | IDA | cellular_component |
| GO:0048704 | Embryonic skeletal system morphogenesis | IEA | biological_process |
| GO:2001234 | Negative regulation of apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6840707534 | 0.2731670377 | 0.9999902473 | 0.9994559061 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0080505849 |
| GSE13712_SHEAR | Down | -0.2053979612 |
| GSE13712_STATIC | Down | -0.0207091026 |
| GSE19018 | Down | -0.0802072685 |
| GSE19899_A1 | Down | -0.3210928109 |
| GSE19899_A2 | Down | -0.0820114102 |
| PubMed_21979375_A1 | Down | -0.3718857305 |
| PubMed_21979375_A2 | Down | -0.0771666473 |
| GSE35957 | Down | -0.0133665596 |
| GSE36640 | Down | -0.0277248345 |
| GSE54402 | Down | -0.1368614833 |
| GSE9593 | Up | 0.0908237266 |
| GSE43922 | Up | 0.0092808700 |
| GSE24585 | Up | 0.4153256340 |
| GSE37065 | Up | 0.0276815824 |
| GSE28863_A1 | Down | -0.1230418357 |
| GSE28863_A2 | Down | -0.1819923892 |
| GSE28863_A3 | Up | 0.0893991891 |
| GSE28863_A4 | Up | 0.0765253820 |
| GSE48662 | Down | -0.0151207416 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-33a-5p | MIMAT0000091 | MIRT028183 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038479 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19636380 | Using tandem affinity purification, we find that CBX7 and CBX8, two Polycomb (Pc) homologs that repress INK4a, both participate in PRC1-like complexes with at least two Posterior sex combs (Psc) proteins, MEL18 and BMI1 |
| 19636380 | In primary human fibroblasts, CBX7, CBX8, MEL18 and BMI1 are present at the INK4a locus and shRNA-mediated knockdown of any one of these components results in de-repression of INK4a and proliferative arrest |
| 18076574 | In this study, functional analyses on the role of the class II polycomb complex in cellular senescence were performed using mouse embryo fibroblasts (MEFs) with a genetically deleted member of the complex, Mel18 |
| 18076574 | The in vivo binding of Ring1b and E2F3b to the ARF promoter decreased progressively in senescence, and Mel18 inactivation accelerated the exfoliation of Ring1b/E2F3b from the promoter sequence, indicating the cooperation of polycombs/E2F3b on ARF expression and cellular senescence |
| 17151361 | Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins |
| 17151361 | Here, we report that Mel-18, a PcG ring finger protein (PCGF) transcriptionally down-regulates Bmi-1 |
| 17151361 | Furthermore, the expression of Bmi-1 and Mel-18 inversely correlates in proliferating and senescent human fibroblasts |
| 17151361 | Bmi-1 down-regulation by Mel-18 results in accelerated senescence and shortening of the replicative life span in normal human cells |
| 17151361 | Finally, our data suggest that Mel-18 regulates Bmi-1 expression during senescence via down-regulation of c-Myc |
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