HCSGD entry for CA1

1. General information

Official gene symbolCA1
Entrez ID759
Gene full namecarbonic anhydrase I
Other gene symbolsCA-I CAB Car1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004089Carbonate dehydratase activityIEAmolecular_function
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006730One-carbon metabolic processIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0015701Bicarbonate transportTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.80590785300.57117932830.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0695887528
GSE13712_SHEARUp0.0753582872
GSE13712_STATICUp0.0377510168
GSE19018Up0.1840169279
GSE19899_A1Up0.2129502326
GSE19899_A2Up0.0413209769
PubMed_21979375_A1Up0.0017199221
PubMed_21979375_A2Down-0.2162432456
GSE35957Up0.3449823605
GSE36640Up0.0392140783
GSE54402Up0.0864139828
GSE9593Up0.0126003299
GSE43922Up0.0068503866
GSE24585Down-0.1520965200
GSE37065Down-0.1177015543
GSE28863_A1Down-0.1117424823
GSE28863_A2Down-0.1405563102
GSE28863_A3Up0.1239405071
GSE28863_A4Down-0.0835247115
GSE48662Down-0.1335093565

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MethyclothiazideDB00232 APRD01104
EthoxzolamideDB00311 APRD00732 | DB07727
MethocarbamolDB00423 APRD01102
BendroflumethiazideDB00436 APRD00666
MethazolamideDB00703 APRD00740
HydroflumethiazideDB00774 APRD01020
ChlorothiazideDB00880 APRD00721
ZonisamideDB00909 APRD00004
HydrochlorothiazideDB00999 APRD00092
TrichlormethiazideDB01021 APRD00031
EthinamateDB01031 APRD00959
DiazoxideDB01119 APRD00914
BrinzolamideDB01194 APRD00475
QuinethazoneDB01325 -
N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDEDB08155 -
3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACIDDB08156 -
ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATEDB08157 -
Ellagic AcidDB08846 DB08468

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-132-3pMIMAT0000426MIRT021737MicroarrayFunctional MTI (Weak)17612493
hsa-miR-26b-5pMIMAT0000083MIRT028780MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

18060755The hippocampal CA1 region from Alzheimer's disease (AD) patients (rapidly sampled) shows a major reduction in NPD1
14992815To explore the molecular mechanisms underlying the increased vulnerability of the aged brain to traumatic brain injury (TBI), we compared the expression of several age-related genes in the CA1, CA3 and dentate gyrus subfields of the young and aged rat hippocampus before and after lateral fluid percussion TBI
8050030It was observed that in the cornu Ammonis, the highest terminin immunoreactivity was present in the pyramidal neurons of CA1
3785534A precocious and progressive deposition of lipofuscin pigment was found in both CA1 and CA3 neurons in Ammon's horn hippocampal fields after 3 and 6 months of alcohol feeding, respectively
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