HCSGD entry for SF1
1. General information
| Official gene symbol | SF1 |
|---|---|
| Entrez ID | 7536 |
| Gene full name | splicing factor 1 |
| Other gene symbols | BBP D11S636 MBBP ZCCHC25 ZFM1 ZNF162 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000245 | Spliceosomal complex assembly | NAS | biological_process |
| GO:0000389 | MRNA 3'-splice site recognition | TAS | biological_process |
| GO:0000398 | MRNA splicing, via spliceosome | IC | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003714 | Transcription corepressor activity | TAS | molecular_function |
| GO:0003723 | RNA binding | IEA TAS | molecular_function |
| GO:0005634 | Nucleus | IDA NAS | cellular_component |
| GO:0005681 | Spliceosomal complex | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005840 | Ribosome | NAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0030238 | Male sex determination | IEA | biological_process |
| GO:0033327 | Leydig cell differentiation | IEA | biological_process |
| GO:0048662 | Negative regulation of smooth muscle cell proliferation | IEA | biological_process |
| GO:0050810 | Regulation of steroid biosynthetic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3522347099 | 0.5754802591 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0815979637 |
| GSE13712_SHEAR | Down | -0.0958089754 |
| GSE13712_STATIC | Down | -0.1465883526 |
| GSE19018 | Down | -0.1406750952 |
| GSE19899_A1 | Down | -0.1318876523 |
| GSE19899_A2 | Up | 0.1075249201 |
| PubMed_21979375_A1 | Down | -0.2299005230 |
| PubMed_21979375_A2 | Up | 0.8335350891 |
| GSE35957 | Down | -0.0502022936 |
| GSE36640 | Down | -0.4437383508 |
| GSE54402 | Up | 0.0188714275 |
| GSE9593 | Down | -0.2818997305 |
| GSE43922 | Up | 0.0012217439 |
| GSE24585 | Up | 0.0962342588 |
| GSE37065 | Down | -0.0674458165 |
| GSE28863_A1 | Up | 0.5609500231 |
| GSE28863_A2 | Up | 0.4049366447 |
| GSE28863_A3 | Up | 0.3135888240 |
| GSE28863_A4 | Up | 0.0124113784 |
| GSE48662 | Down | -0.0849158188 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-186-5p | MIMAT0000456 | MIRT021119 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-935 | MIMAT0004978 | MIRT036661 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044484 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046884 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
