HCSGD entry for ZAP70

1. General information

Official gene symbolZAP70
Entrez ID7535
Gene full namezeta-chain (TCR) associated protein kinase 70kDa
Other gene symbolsSRK STCD STD TZK ZAP-70
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001772Immunological synapseIEAcellular_component
GO:0001784Phosphotyrosine bindingIEAmolecular_function
GO:0002250Adaptive immune responseTASbiological_process
GO:0004713Protein tyrosine kinase activityIDA NAS TASmolecular_function
GO:0004715Non-membrane spanning protein tyrosine kinase activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingNASmolecular_function
GO:0005737CytoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006468Protein phosphorylationIDA NASbiological_process
GO:0006955Immune responseIDAbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0030217T cell differentiationNASbiological_process
GO:0035556Intracellular signal transductionNASbiological_process
GO:0042101T cell receptor complexIDAcellular_component
GO:0042110T cell activationTASbiological_process
GO:0042113B cell activationTASbiological_process
GO:0043366Beta selectionIEAbiological_process
GO:0045059Positive thymic T cell selectionIDAbiological_process
GO:0045060Negative thymic T cell selectionIEAbiological_process
GO:0045582Positive regulation of T cell differentiationIDAbiological_process
GO:0046638Positive regulation of alpha-beta T cell differentiationIEAbiological_process
GO:0046641Positive regulation of alpha-beta T cell proliferationIEAbiological_process
GO:0046777Protein autophosphorylationIEAbiological_process
GO:0050850Positive regulation of calcium-mediated signalingIEAbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0070489T cell aggregationTASbiological_process
GO:0072678T cell migrationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.84464527560.54641226400.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1427452457
GSE13712_SHEARUp0.0333406294
GSE13712_STATICUp0.0571938783
GSE19018Down-0.0522377622
GSE19899_A1Down-0.0178511728
GSE19899_A2Down-0.1419234718
PubMed_21979375_A1Down-0.0919193994
PubMed_21979375_A2Down-0.1334199353
GSE35957Up0.0738142520
GSE36640Down-0.0546623640
GSE54402Down-0.0888032570
GSE9593Up0.1156406323
GSE43922Up0.0282956150
GSE24585Down-0.0259146399
GSE37065Down-0.1578785822
GSE28863_A1Down-0.0139602801
GSE28863_A2Down-0.0525586789
GSE28863_A3Up0.4349600378
GSE28863_A4Up0.0580110911
GSE48662Up0.0034732384

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

StaurosporineDB02010 EXPT02970 | EXPT02972

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-34a-5pMIMAT0000255MIRT005760Immunoblot//Luciferase reporter assayFunctional MTI21205967
hsa-miR-34a-5pMIMAT0000255MIRT005760ProteomicsFunctional MTI (Weak)21566225
hsa-miR-34b-3pMIMAT0004676MIRT005761Immunoblot//Luciferase reporter assayFunctional MTI21205967
hsa-miR-34c-5pMIMAT0000686MIRT005762Immunoblot//Luciferase reporter assayFunctional MTI21205967
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.