HCSGD entry for YWHAZ

1. General information

Official gene symbolYWHAZ
Entrez ID7534
Gene full nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
Other gene symbols14-3-3-zeta KCIP-1 YWHAD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002553Histamine secretion by mast cellIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmTAScellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006626Protein targeting to mitochondrionIEAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0010941Regulation of cell deathIEAbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0016301Kinase activityIEAmolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030168Platelet activationTASbiological_process
GO:0030659Cytoplasmic vesicle membraneTAScellular_component
GO:0031252Cell leading edgeIEAcellular_component
GO:0032403Protein complex bindingIEAmolecular_function
GO:0042470MelanosomeIEAcellular_component
GO:0042629Mast cell granuleIEAcellular_component
GO:0042802Identical protein bindingIPImolecular_function
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0070062Extracellular vesicular exosomeIDAcellular_component
GO:0097193Intrinsic apoptotic signaling pathwayTASbiological_process
GO:1900740Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.67000368910.60884969800.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0518700280
GSE13712_SHEARUp0.3338747122
GSE13712_STATICUp0.1101008348
GSE19018Up0.0895138175
GSE19899_A1Down-0.0742211383
GSE19899_A2Down-0.2286366692
PubMed_21979375_A1Down-0.2943945300
PubMed_21979375_A2Down-0.2697980390
GSE35957Down-0.0488864274
GSE36640Down-0.0049554626
GSE54402Down-0.0412304809
GSE9593Up0.0376016301
GSE43922Up0.0089632597
GSE24585Up0.0889271613
GSE37065Up0.0650628755
GSE28863_A1Down-0.1006396022
GSE28863_A2Up0.3613692570
GSE28863_A3Up0.0252222173
GSE28863_A4Up0.0291157618
GSE48662Up0.0251687835

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT006983Luciferase reporter assay//Reporter assay;ProteomicsFunctional MTI21512034
hsa-miR-193b-3pMIMAT0002819MIRT006983CLASHFunctional MTI (Weak)23622248
hsa-miR-375MIMAT0000728MIRT019886Reporter assay;Western blot;qRT-PCR;MicroarrayFunctional MTI20215506
hsa-miR-155-5pMIMAT0000646MIRT020711Reporter assay;OtherNon-Functional MTI20584899
hsa-miR-1MIMAT0000416MIRT023741ProteomicsFunctional MTI (Weak)18668040
hsa-miR-30a-5pMIMAT0000087MIRT028537ProteomicsFunctional MTI (Weak)18668040
hsa-miR-1229-3pMIMAT0005584MIRT036384CLASHFunctional MTI (Weak)23622248
hsa-miR-877-3pMIMAT0004950MIRT036887CLASHFunctional MTI (Weak)23622248
hsa-miR-455-3pMIMAT0004784MIRT037891CLASHFunctional MTI (Weak)23622248
hsa-miR-423-5pMIMAT0004748MIRT038013CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039656CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041843CLASHFunctional MTI (Weak)23622248
hsa-miR-340-3pMIMAT0000750MIRT043854CLASHFunctional MTI (Weak)23622248
hsa-miR-378a-3pMIMAT0000732MIRT043950CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052271CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-375MIMAT0000728NAhsa-miR-375{Western blot}{overexpression by miRNA precursor transfection}20215506
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21191810In a previous study, we found that secretory phospholipase A(2) (sPLA(2)) induced cellular senescence in human dermal fibroblasts (HDFs)
19264704Induction of cellular senescence by secretory phospholipase A2 in human dermal fibroblasts through an ROS-mediated p53 pathway
19264704Secretory phospholipase A(2) (sPLA(2)) is involved in various cellular physiological and pathological responses, especially in inflammatory responses
19197340We report that knockdown of the M-type receptor PLA2R (phospholipase A2 receptor) prevents the onset of replicative senescence and diminishes stress-induced senescence
7082006Membrane alterations in cellular aging: susceptibility of phospholipids in density (age)-separated human erythrocytes to phospholipase A2
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