HCSGD entry for XRCC5
1. General information
| Official gene symbol | XRCC5 |
|---|---|
| Entrez ID | 7520 |
| Gene full name | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) |
| Other gene symbols | KARP-1 KARP1 KU80 KUB2 Ku86 NFIV |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000723 | Telomere maintenance | IEA TAS | biological_process |
| GO:0000783 | Nuclear telomere cap complex | TAS | cellular_component |
| GO:0000784 | Nuclear chromosome, telomeric region | IDA | cellular_component |
| GO:0003677 | DNA binding | NAS | molecular_function |
| GO:0003684 | Damaged DNA binding | IEA | molecular_function |
| GO:0003690 | Double-stranded DNA binding | TAS | molecular_function |
| GO:0003691 | Double-stranded telomeric DNA binding | IDA | molecular_function |
| GO:0004003 | ATP-dependent DNA helicase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006200 | ATP catabolic process | TAS | biological_process |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006302 | Double-strand break repair | TAS | biological_process |
| GO:0006303 | Double-strand break repair via nonhomologous end joining | IEA IMP TAS | biological_process |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0032481 | Positive regulation of type I interferon production | TAS | biological_process |
| GO:0032508 | DNA duplex unwinding | TAS | biological_process |
| GO:0042162 | Telomeric DNA binding | IDA IEA | molecular_function |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0043564 | Ku70:Ku80 complex | IDA IEA | cellular_component |
| GO:0044212 | Transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0050769 | Positive regulation of neurogenesis | IEA | biological_process |
| GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity | IMP | molecular_function |
| GO:0060218 | Hematopoietic stem cell differentiation | IEA | biological_process |
| GO:0070419 | Nonhomologous end joining complex | IDA | cellular_component |
| GO:0071398 | Cellular response to fatty acid | IEA | biological_process |
| GO:0071475 | Cellular hyperosmotic salinity response | IEA | biological_process |
| GO:0071481 | Cellular response to X-ray | IEA | biological_process |
| GO:0075713 | Establishment of integrated proviral latency | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9275155275 | 0.0972586490 | 0.9999902473 | 0.5950592515 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0090738673 |
| GSE13712_SHEAR | Down | -0.0989363617 |
| GSE13712_STATIC | Down | -0.1711361819 |
| GSE19018 | Down | -0.3090137602 |
| GSE19899_A1 | Down | -0.1171027001 |
| GSE19899_A2 | Down | -0.5113956313 |
| PubMed_21979375_A1 | Down | -0.0387297201 |
| PubMed_21979375_A2 | Down | -0.3156885596 |
| GSE35957 | Down | -0.2234644801 |
| GSE36640 | Down | -0.6454331409 |
| GSE54402 | Up | 0.2487661100 |
| GSE9593 | Down | -0.4015682478 |
| GSE43922 | Down | -0.0203219227 |
| GSE24585 | Down | -0.0833451565 |
| GSE37065 | Up | 0.0399369557 |
| GSE28863_A1 | Up | 0.2826961929 |
| GSE28863_A2 | Up | 0.6171097487 |
| GSE28863_A3 | Down | -0.0010364224 |
| GSE28863_A4 | Down | -0.0330038133 |
| GSE48662 | Down | -0.6322352844 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-484 | MIMAT0002174 | MIRT042031 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043483 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT047762 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048471 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT050041 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 16 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24244594 | To test this hypothesis, we determined the levels of gammaH2AX (a marker for DNA double-strand breaks) as well as non-homologous end joining proteins (Ku70 and Ku80) in lungs of mice exposed to CS |
| 24244594 | Furthermore, p21 deletion reduced the level of gammaH2AX, but augmented the levels of Ku70, Ku80, and PAR in lungs by CS |
| 21469181 | E(2) had no regulatory effects on the expression rates of the cell cycle regulator p21 and the DNA repair proteins SIRT1 and XRCC5 |
| 21376036 | SIRT1 and XRCC5 were up-regulated after oxidant insult and expression levels increased in aging cells |
| 21037379 | Additionally, depletion of tankyrase 1 resulted in concomitant and rapid reduction of the nonhomologous end-joining protein DNA-PKcs, while Ku86 and ATM protein levels remained unchanged; DNA-PKcs mRNA levels were also unaffected |
| 20148697 | PURPOSE: To investigate the radiosensitising effect of Ku autoantigen 70 (Ku70) and Ku autoantigen 80 (Ku80) knockdown by lentivirus-mediated RNA interference (RNAi) in the MCF10A immortalised human mammary epithelial cell line |
| 20148697 | RESULTS: Western blot analysis showed that the Ku70 lentiviral vector was effective in silencing the expression of both Ku70 and Ku80 |
| 19946467 | Here we showed that Ku86 deficiency accelerated the high NaCl-induced cellular senescence |
| 19946467 | We find that 1) high NaCl induces rapid cellular senescence in Ku86 deficient(xrs5) cells, 2) Ku86 deficiency shortens lifespan of C |
| 19946467 | Further, although water balance is known to be compromised in old mice, this occurs at much earlier age in Ku86(-/-) mice |
| 19946467 | When subjected to mild water restriction, 3 month old Ku86(-/-), but not Ku86(+/+),mice rapidly become dehydrated as evidenced by decrease in body weight, increased production of antidiuretic hormone,increased urine osmolality and decreased urine volume |
| 19946467 | We conclude that Ku86 deficiency accelerates high NaCl(-) induced cellular senescence,particularly in the renal medulla where NaCl normally is high |
| 19597334 | Ku80 is often referred to as a tumor suppressor since it maintains the genome by repairing DNA double-strand breaks (DSBs) via the nonhomologous end joining (NHEJ) pathway |
| 19597334 | Even though Ku80 deletion causes hypersensitivity to gamma-radiation, DNA damage and chromosomal rearrangements, Ku80-mutant mice exhibit very low cancer levels |
| 19597334 | In addition, Ku80 and p53 show a genetic interaction to suppress pro-B cell lymphoma and medulloblastoma |
| 19535900 | Recently, we reported the effect of loss of function of p21, a gene implicated in p53-induced cellular senescence, in the background of the Ku80(-/-) premature aging mouse (Zhao et al |
| 19188702 | Here we describe human cells that express fusions between the large human Ku subunit (Ku86) and a fluorescent protein tag |
| 19188702 | These data are consistent with models in which Ku recruits telomerase to telomeres or activates recruited telomerase and suggest that the Ku86 fusion proteins specifically block this role |
| 19079133 | Ku80 is important in the repair of DNA double-strand breaks by its essential function in non-homologous end-joining |
| 19079133 | The absence of Ku80 causes the accumulation of DNA damage and leads to premature ageing in mice |
| 18941635 | Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells |
| 18941635 | Indeed, we found a substantial increase in persistent 53BP1 and gammaH2AX DNA damage foci in Ku80-/- as compared to wild-type liver |
| 17686666 | Here, we show that the levels of Ku70 and Ku80 drop approximately twofold in replicatively senescent cells |
| 17347130 | Using a cell-free NHEJ assay, we have investigated the ability of three Chinese hamster ovary (CHO) mutants deficient in Ku80 (xrs6), DNA-PKcs (XR-C1) and XRCC4 (XR-1) in comparison with CHO-K1 wild-type cells to rejoin non-compatible DSB ends |
| 17202845 | All the other DSB repair proteins tested, Sir2, TRF1 and Ku80, did not show any significant differences upon aging |
| 17173483 | Interestingly, a similar perturbation of the postnatal growth axis was not detected in another progeroid mouse model, the double-strand DNA break repair deficient Ku80(-/-) mouse |
| 10606813 | Senescent human fibroblasts have elevated Ku86 proteolytic cleavage activity |
| 10606813 | However, further studies indicate that cleavage of Ku86 could be inhibited by including leupeptin in the extraction buffer, and no 69 kDa variant was evident in the cell |
| 10606813 | In fact, the levels of Ku86, Ku70 and DNA-end binding activity of Ku remained unchanged during replicative senescence |
| 10606813 | Thus, this study reveals an intriguing protease in HDFs, and also indicates that inconsistent results of Ku86 expression will be obtained if the protease activity is not completely inhibited |
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