HCSGD entry for XRCC3
1. General information
| Official gene symbol | XRCC3 |
|---|---|
| Entrez ID | 7517 |
| Gene full name | X-ray repair complementing defective repair in Chinese hamster cells 3 |
| Other gene symbols | CMM6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0006259 | DNA metabolic process | IEA | biological_process |
| GO:0006281 | DNA repair | IGI | biological_process |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | TAS | biological_process |
| GO:0008094 | DNA-dependent ATPase activity | IEA | molecular_function |
| GO:0010033 | Response to organic substance | IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6890295847 | 0.3768725770 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1941286908 |
| GSE13712_SHEAR | Up | 0.3312551907 |
| GSE13712_STATIC | Up | 0.0404716664 |
| GSE19018 | Up | 0.2270904165 |
| GSE19899_A1 | Up | 0.0501926077 |
| GSE19899_A2 | Down | -0.0430245709 |
| PubMed_21979375_A1 | Down | -0.1749515536 |
| PubMed_21979375_A2 | Down | -0.1841236524 |
| GSE35957 | Down | -0.1120669745 |
| GSE36640 | Down | -0.2049244626 |
| GSE54402 | Down | -0.0110576135 |
| GSE9593 | Down | -0.2837500599 |
| GSE43922 | Up | 0.0543691166 |
| GSE24585 | Down | -0.1224612415 |
| GSE37065 | Down | -0.0277551008 |
| GSE28863_A1 | Down | -0.0309344962 |
| GSE28863_A2 | Down | -0.0448822289 |
| GSE28863_A3 | Up | 0.0323229737 |
| GSE28863_A4 | Up | 0.0721893262 |
| GSE48662 | Down | -0.7333406642 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18212065 | The mechanism of circle formation in WS cells does not involve XRCC3 function |
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