HCSGD entry for XRCC2
1. General information
| Official gene symbol | XRCC2 |
|---|---|
| Entrez ID | 7516 |
| Gene full name | X-ray repair complementing defective repair in Chinese hamster cells 2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000724 | Double-strand break repair via homologous recombination | IEA | biological_process |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006281 | DNA repair | IGI | biological_process |
| GO:0007126 | Meiosis | TAS | biological_process |
| GO:0008094 | DNA-dependent ATPase activity | IEA | molecular_function |
| GO:0010165 | Response to X-ray | IEA | biological_process |
| GO:0010332 | Response to gamma radiation | IEA | biological_process |
| GO:0043524 | Negative regulation of neuron apoptotic process | IEA | biological_process |
| GO:0050769 | Positive regulation of neurogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7173201930 | 0.0105197447 | 0.9999902473 | 0.2024051170 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0730926214 |
| GSE13712_SHEAR | Up | 0.2587750152 |
| GSE13712_STATIC | Up | 0.1526674281 |
| GSE19018 | Up | 0.4045873995 |
| GSE19899_A1 | Down | -0.0788610773 |
| GSE19899_A2 | Down | -1.3923338418 |
| PubMed_21979375_A1 | Down | -0.7218670454 |
| PubMed_21979375_A2 | Down | -0.5420154764 |
| GSE35957 | Down | -0.2888635471 |
| GSE36640 | Down | -0.5745662590 |
| GSE54402 | Down | -0.1416290518 |
| GSE9593 | Down | -0.4045548179 |
| GSE43922 | Down | -1.3763146222 |
| GSE24585 | Down | -0.1540582041 |
| GSE37065 | Down | -0.4657873823 |
| GSE28863_A1 | Down | -0.3781893251 |
| GSE28863_A2 | Up | 1.3013688428 |
| GSE28863_A3 | Down | -0.3481695940 |
| GSE28863_A4 | Down | -0.4295950133 |
| GSE48662 | Down | -0.0405819128 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022131 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028843 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
