HCSGD entry for XPO1
1. General information
| Official gene symbol | XPO1 |
|---|---|
| Entrez ID | 7514 |
| Gene full name | exportin 1 (CRM1 homolog, yeast) |
| Other gene symbols | CRM1 emb exp1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000776 | Kinetochore | IDA | cellular_component |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005215 | Transporter activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005635 | Nuclear envelope | TAS | cellular_component |
| GO:0005642 | Annulate lamellae | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006611 | Protein export from nucleus | IEA | biological_process |
| GO:0006886 | Intracellular protein transport | IEA | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0008536 | Ran GTPase binding | IEA | molecular_function |
| GO:0008565 | Protein transporter activity | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010824 | Regulation of centrosome duplication | IEA | biological_process |
| GO:0015030 | Cajal body | IEA | cellular_component |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0019058 | Viral life cycle | TAS | biological_process |
| GO:0019904 | Protein domain specific binding | IEA | molecular_function |
| GO:0030512 | Negative regulation of transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0030529 | Ribonucleoprotein complex | IDA | cellular_component |
| GO:0034504 | Protein localization to nucleus | IEA | biological_process |
| GO:0042176 | Regulation of protein catabolic process | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0046825 | Regulation of protein export from nucleus | IEA | biological_process |
| GO:0051028 | MRNA transport | IEA | biological_process |
| GO:0075733 | Intracellular transport of virus | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9721962995 | 0.0155318681 | 0.9999902473 | 0.2446159619 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0003305095 |
| GSE13712_SHEAR | Up | 0.3392545538 |
| GSE13712_STATIC | Down | -0.0122492166 |
| GSE19018 | Up | 0.2869442820 |
| GSE19899_A1 | Down | -0.2379086063 |
| GSE19899_A2 | Down | -0.8848643144 |
| PubMed_21979375_A1 | Down | -0.5780369025 |
| PubMed_21979375_A2 | Down | -0.9113108946 |
| GSE35957 | Down | -0.4887969038 |
| GSE36640 | Down | -0.4768998617 |
| GSE54402 | Down | -0.0707275043 |
| GSE9593 | Down | -0.1703031171 |
| GSE43922 | Down | -0.5590088411 |
| GSE24585 | Down | -0.0595343421 |
| GSE37065 | Up | 0.1340552005 |
| GSE28863_A1 | Down | -0.1440603841 |
| GSE28863_A2 | Up | 0.1752516859 |
| GSE28863_A3 | Down | -0.5990707668 |
| GSE28863_A4 | Down | -0.1647037977 |
| GSE48662 | Down | -1.0094758911 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016294 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020549 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026224 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028476 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031490 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1236-3p | MIMAT0005591 | MIRT036257 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045717 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046310 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049604 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-3p | MIMAT0000071 | MIRT050787 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26864624 | The RCC1-induced inhibition of senescence required Ran and exportin 1 and involved the activation of importin beta-dependent nuclear import of 53BP1, a large NCT cargo |
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