HCSGD entry for XPA
1. General information
| Official gene symbol | XPA |
|---|---|
| Entrez ID | 7507 |
| Gene full name | xeroderma pigmentosum, complementation group A |
| Other gene symbols | XP1 XPAC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000718 | Nucleotide-excision repair, DNA damage removal | TAS | biological_process |
| GO:0003684 | Damaged DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006289 | Nucleotide-excision repair | IEA TAS | biological_process |
| GO:0006979 | Response to oxidative stress | IEA | biological_process |
| GO:0008630 | Intrinsic apoptotic signaling pathway in response to DNA damage | IEA | biological_process |
| GO:0009411 | Response to UV | IEA | biological_process |
| GO:0009636 | Response to toxic substance | IEA | biological_process |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0035264 | Multicellular organism growth | IEA | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4307527412 | 0.2139950382 | 0.9999902473 | 0.8932312242 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2471642609 |
| GSE13712_SHEAR | Up | 0.0701037347 |
| GSE13712_STATIC | Up | 0.0478010675 |
| GSE19018 | Up | 0.1054367418 |
| GSE19899_A1 | Down | -0.3627129385 |
| GSE19899_A2 | Up | 0.4248157801 |
| PubMed_21979375_A1 | Down | -0.9551391384 |
| PubMed_21979375_A2 | Down | -0.0250265332 |
| GSE35957 | Up | 0.0526393875 |
| GSE36640 | Up | 0.2967542123 |
| GSE54402 | Down | -0.3116111640 |
| GSE9593 | Up | 0.2052711810 |
| GSE43922 | Down | -0.3088792500 |
| GSE24585 | Up | 0.1773316259 |
| GSE37065 | Up | 0.0531034583 |
| GSE28863_A1 | Up | 0.0395490082 |
| GSE28863_A2 | Up | 0.2417967985 |
| GSE28863_A3 | Down | -0.2759215739 |
| GSE28863_A4 | Down | -0.2224787622 |
| GSE48662 | Down | -0.2049523133 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-210-3p | MIMAT0000267 | MIRT003917 | Western blot | Non-Functional MTI | 19141645 |
| hsa-miR-373-3p | MIMAT0000726 | MIRT003918 | Western blot | Non-Functional MTI | 19141645 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT004137 | Microarray | Functional MTI (Weak) | 16822819 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17848622 | Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A |
| 17848622 | Strikingly, these XPA foci colocalized with the DSB sites in the progeroid cells |
| 17848622 | RNA interference (RNAi) knockdown of XPA in HGPS cells partially restored DSB repair as evidenced by Western blot analysis, immunofluorescence and comet assays |
| 17848622 | We propose that the uncharacteristic localization of XPA to or near DSBs inhibits DSB repair, thereby contributing to the premature aging phenotypes observed in progeria arising from genetic defects in prelamin A maturation |
Entries Per Page
Displaying Page of
