HCSGD entry for XDH

1. General information

Official gene symbolXDH
Entrez ID7498
Gene full namexanthine dehydrogenase
Other gene symbolsXO XOR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001933Negative regulation of protein phosphorylationIDAbiological_process
GO:0001937Negative regulation of endothelial cell proliferationIDAbiological_process
GO:0004854Xanthine dehydrogenase activityIDAmolecular_function
GO:0004855Xanthine oxidase activityEXP IDAmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005777PeroxisomeIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006144Purine nucleobase metabolic processTASbiological_process
GO:0006195Purine nucleotide catabolic processTASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0007595LactationIEAbiological_process
GO:0008762UDP-N-acetylmuramate dehydrogenase activityIEAmolecular_function
GO:0009055Electron carrier activityIEAmolecular_function
GO:0009115Xanthine catabolic processIDAbiological_process
GO:0010629Negative regulation of gene expressionIDAbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043546Molybdopterin cofactor bindingIDAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045602Negative regulation of endothelial cell differentiationIDAbiological_process
GO:0050660Flavin adenine dinucleotide bindingIDAmolecular_function
GO:00515372 iron, 2 sulfur cluster bindingIDAmolecular_function
GO:0051898Negative regulation of protein kinase B signalingIDAbiological_process
GO:0055086Nucleobase-containing small molecule metabolic processTASbiological_process
GO:1900745Positive regulation of p38MAPK cascadeIDAbiological_process
GO:1900747Negative regulation of vascular endothelial growth factor signaling pathwayIDAbiological_process
GO:2000379Positive regulation of reactive oxygen species metabolic processIDAbiological_process
GO:2001213Negative regulation of vasculogenesisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00628974580.97651399260.21012906091.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0014597766
GSE13712_SHEARDown-0.0588275178
GSE13712_STATICDown-0.0080940461
GSE19018Down-0.0199574185
GSE19899_A1Up0.7821269999
GSE19899_A2Up2.2508101762
PubMed_21979375_A1Up2.0463078082
PubMed_21979375_A2Up2.7801219376
GSE35957Up0.1481704128
GSE36640Up0.0985521499
GSE54402Up0.4985482634
GSE9593Up0.0462821405
GSE43922Up1.0133227963
GSE24585Up0.0796989342
GSE37065Down-0.0456798879
GSE28863_A1Up0.1921343713
GSE28863_A2Up0.4224188124
GSE28863_A3Up0.0379895769
GSE28863_A4Down-0.0209619943
GSE48662Down-0.3565722300

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-CarnitineDB00583 APRD01070
4-[5-Pyridin-4-Yl-1h-[1,2,4]Triazol-3-Yl]-Pyridine-2-CarbonitrileDB01685 EXPT01517
dioxothiomolybdenum(VI) ionDB03328 EXPT02214
EniluracilDB03516 EXPT03299
Y-700DB03841 EXPT03278
FebuxostatDB04854 DB03786
OxypurinolDB05262 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT028928MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24343903Synthesis, antioxidant, and xanthine oxidase inhibitory activities of 5-[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione derivatives
24343903Xanthine oxidase (XO) is a complex metalloflavoprotein, the overproduction of which usually leads to a pathological condition called gout
23177727Xanthine oxidase (XO) generates superoxide anions and H(2)O(2) for the self-defence system of organism
23024373This was accompanied by increases in xanthine oxidase (P<0
22907303Western blot was used to analyze the expression levels of xanthine oxidase (XOD), manganese-superoxide dismutase (Mn-SOD) and the subunits p67(phox) of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in the HUVECs
6896544The role of membrane peroxidation in red cell aging was investigated by exposing rat erythrocytes to a peroxide-generating system of xanthine oxidase with hypoxanthine, and the resulting alterations were compared to those observed during in vivo aging
6893680The activity of xanthine oxidase, a cytoplasmic enzyme, was 5- to 6-fold lower in the tumor
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