HCSGD entry for WNT5A

1. General information

Official gene symbolWNT5A
Entrez ID7474
Gene full namewingless-type MMTV integration site family, member 5A
Other gene symbolshWNT5A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityIDAbiological_process
GO:0001667Ameboidal cell migrationIEAbiological_process
GO:0001736Establishment of planar polarityIEAbiological_process
GO:0001756SomitogenesisIEAbiological_process
GO:0001837Epithelial to mesenchymal transitionIEPbiological_process
GO:0001843Neural tube closureIEAbiological_process
GO:0001938Positive regulation of endothelial cell proliferationIMPbiological_process
GO:0001947Heart loopingIEAbiological_process
GO:0002053Positive regulation of mesenchymal cell proliferationIEAbiological_process
GO:0002088Lens development in camera-type eyeISSbiological_process
GO:0002741Positive regulation of cytokine secretion involved in immune responseIMPbiological_process
GO:0003323Type B pancreatic cell developmentIEAbiological_process
GO:0003408Optic cup formation involved in camera-type eye developmentISSbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIMPmolecular_function
GO:0005102Receptor bindingIEAmolecular_function
GO:0005109Frizzled bindingIPImolecular_function
GO:0005110Frizzled-2 bindingIEAmolecular_function
GO:0005115Receptor tyrosine kinase-like orphan receptor bindingIPImolecular_function
GO:0005125Cytokine activityIEAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006468Protein phosphorylationIEAbiological_process
GO:0007223Wnt signaling pathway, calcium modulating pathwayIDA IMPbiological_process
GO:0007257Activation of JUN kinase activityIDA IMPbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0007411Axon guidanceISSbiological_process
GO:0007442Hindgut morphogenesisIEAbiological_process
GO:0007494Midgut developmentIEAbiological_process
GO:0008584Male gonad developmentIEPbiological_process
GO:0008595Anterior/posterior axis specification, embryoIEAbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0010033Response to organic substanceIEPbiological_process
GO:0010469Regulation of receptor activityICbiological_process
GO:0010595Positive regulation of endothelial cell migrationIMPbiological_process
GO:0010800Positive regulation of peptidyl-threonine phosphorylationIEAbiological_process
GO:0010820Positive regulation of T cell chemotaxisIMPbiological_process
GO:0010976Positive regulation of neuron projection developmentISSbiological_process
GO:0016055Wnt signaling pathwayIDA IEAbiological_process
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0021891Olfactory bulb interneuron developmentISSbiological_process
GO:0030182Neuron differentiationIBA ISSbiological_process
GO:0030216Keratinocyte differentiationIEPbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0030514Negative regulation of BMP signaling pathwayIEAbiological_process
GO:0030825Positive regulation of cGMP metabolic processIDAbiological_process
GO:0032148Activation of protein kinase B activityIDAbiological_process
GO:0032729Positive regulation of interferon-gamma productionIEAbiological_process
GO:0032755Positive regulation of interleukin-6 productionIMPbiological_process
GO:0033138Positive regulation of peptidyl-serine phosphorylationIEAbiological_process
GO:0034613Cellular protein localizationIDAbiological_process
GO:0036342Post-anal tail morphogenesisIEAbiological_process
GO:0038031Non-canonical Wnt signaling pathway via JNK cascadeIEAbiological_process
GO:0040037Negative regulation of fibroblast growth factor receptor signaling pathwayIEAbiological_process
GO:0042060Wound healingIDAbiological_process
GO:0042733Embryonic digit morphogenesisIEAbiological_process
GO:0043032Positive regulation of macrophage activationIMPbiological_process
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045080Positive regulation of chemokine biosynthetic processIMPbiological_process
GO:0045165Cell fate commitmentIBAbiological_process
GO:0045599Negative regulation of fat cell differentiationIMPbiological_process
GO:0045732Positive regulation of protein catabolic processIGIbiological_process
GO:0045766Positive regulation of angiogenesisIMPbiological_process
GO:0045778Positive regulation of ossificationIMPbiological_process
GO:0045836Positive regulation of meiosisIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0046330Positive regulation of JNK cascadeIEAbiological_process
GO:0048018Receptor agonist activityICmolecular_function
GO:0048146Positive regulation of fibroblast proliferationIDAbiological_process
GO:0048706Embryonic skeletal system developmentIMPbiological_process
GO:0048806Genitalia developmentIMPbiological_process
GO:0048843Negative regulation of axon extension involved in axon guidanceIEAbiological_process
GO:0048850Hypophysis morphogenesisIEAbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIEAbiological_process
GO:0050718Positive regulation of interleukin-1 beta secretionIMPbiological_process
GO:0050729Positive regulation of inflammatory responseIMPbiological_process
GO:0050919Negative chemotaxisIEAbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0051216Cartilage developmentIEAbiological_process
GO:0051964Negative regulation of synapse assemblyIEAbiological_process
GO:0060021Palate developmentIMPbiological_process
GO:0060029Convergent extension involved in organogenesisIEAbiological_process
GO:0060065Uterus developmentIEAbiological_process
GO:0060067Cervix developmentIEAbiological_process
GO:0060068Vagina developmentIEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIEAbiological_process
GO:0060157Urinary bladder developmentIEAbiological_process
GO:0060324Face developmentIMPbiological_process
GO:0060340Positive regulation of type I interferon-mediated signaling pathwayIDAbiological_process
GO:0060599Lateral sprouting involved in mammary gland duct morphogenesisIEAbiological_process
GO:0060638Mesenchymal-epithelial cell signalingIEAbiological_process
GO:0060686Negative regulation of prostatic bud formationIEAbiological_process
GO:0060744Mammary gland branching involved in thelarcheIEAbiological_process
GO:0060750Epithelial cell proliferation involved in mammary gland duct elongationIEAbiological_process
GO:0060760Positive regulation of response to cytokine stimulusIDAbiological_process
GO:0060762Regulation of branching involved in mammary gland duct morphogenesisIEAbiological_process
GO:0060907Positive regulation of macrophage cytokine productionIMPbiological_process
GO:0061036Positive regulation of cartilage developmentIEAbiological_process
GO:0061347Planar cell polarity pathway involved in outflow tract morphogenesisIEAbiological_process
GO:0061348Planar cell polarity pathway involved in ventricular septum morphogenesisIEAbiological_process
GO:0061349Planar cell polarity pathway involved in cardiac right atrium morphogenesisIEAbiological_process
GO:0061350Planar cell polarity pathway involved in cardiac muscle tissue morphogenesisIEAbiological_process
GO:0061354Planar cell polarity pathway involved in pericardium morphogenesisIEAbiological_process
GO:0070245Positive regulation of thymocyte apoptotic processIEAbiological_process
GO:0071222Cellular response to lipopolysaccharideIEPbiological_process
GO:0071277Cellular response to calcium ionIEPbiological_process
GO:0071300Cellular response to retinoic acidISSbiological_process
GO:0071346Cellular response to interferon-gammaIEPbiological_process
GO:0071425Hematopoietic stem cell proliferationIDAbiological_process
GO:0071542Dopaminergic neuron differentiationIEAbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIEPbiological_process
GO:0072201Negative regulation of mesenchymal cell proliferationIDAbiological_process
GO:0090009Primitive streak formationIEAbiological_process
GO:0090037Positive regulation of protein kinase C signalingIMPbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIDA IGIbiological_process
GO:0090103Cochlea morphogenesisIEAbiological_process
GO:0090179Planar cell polarity pathway involved in neural tube closureIEAbiological_process
GO:2000049Positive regulation of cell-cell adhesion mediated by cadherinIEAbiological_process
GO:2000273Positive regulation of receptor activityICbiological_process
GO:2000484Positive regulation of interleukin-8 secretionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.74812655670.02160076360.99999024730.2837565455

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4795230682
GSE13712_SHEARDown-0.1970692869
GSE13712_STATICUp0.0071496979
GSE19018Up0.2592116200
GSE19899_A1Down-0.1523152957
GSE19899_A2Down-0.2983392362
PubMed_21979375_A1Down-0.8289889251
PubMed_21979375_A2Up0.0118978480
GSE35957Down-0.0441141718
GSE36640Up0.0233960459
GSE54402Down-0.2251133543
GSE9593Down-0.2510490664
GSE43922Down-0.2860179624
GSE24585Up0.2770423295
GSE37065Up0.2242901226
GSE28863_A1Down-0.3405004238
GSE28863_A2Up0.4708295503
GSE28863_A3Up0.3418011355
GSE28863_A4Down-0.8190133378
GSE48662Down-0.3792031763

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30a-5pMIMAT0000087MIRT005162pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-155-5pMIMAT0000646MIRT020965ProteomicsFunctional MTI (Weak)20584899
hsa-miR-186-5pMIMAT0000456MIRT021154SequencingFunctional MTI (Weak)20371350
hsa-miR-21-5pMIMAT0000076MIRT030983MicroarrayFunctional MTI (Weak)18591254
hsa-miR-16-5pMIMAT0000069MIRT031969ProteomicsFunctional MTI (Weak)18668040
hsa-miR-92a-3pMIMAT0000092MIRT049710CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24141946Here we report an unexpected shift from canonical to non-canonical Wnt signalling in mice due to elevated expression of Wnt5a in aged HSCs, which causes stem-cell ageing
24141946Wnt5a treatment of young HSCs induces ageing-associated stem-cell apolarity, reduction of regenerative capacity and an ageing-like myeloid-lymphoid differentiation skewing via activation of the small Rho GTPase Cdc42
24141946Conversely, Wnt5a haploinsufficiency attenuates HSC ageing, whereas stem-cell-intrinsic reduction of Wnt5a expression results in functionally rejuvenated aged HSCs
24141946Our data demonstrate a critical role for stem-cell-intrinsic non-canonical Wnt5a signalling in HSC ageing
22724383P53, p21, Wnt3a, Wnt5a, sonic hedgehog (Shh) mRNA was detected by Real time polymerase chain reaction (PCR) and Wnt5a protein was determined by Western blot
22724383A remarkable up-regulation of Wnt5a mRNA expression ( approximately 269-fold) and protein expression was seen 72 h after radiation
21816908Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence
21816908Wnt5a is a noncanonical Wnt ligand that plays a context-dependent role in human cancers
21816908Here, we investigate the role of Wnt5a in regulating senescence of EOC cells
21816908We show that Wnt5a is expressed at significantly lower levels in human EOC cell lines and in primary human EOCs (n = 130) compared with either normal ovarian surface epithelium (n = 31; P = 0
21816908Notably, a lower level of Wnt5a expression correlates with tumor stage (P = 0
21816908Significantly, restoration of Wnt5a expression inhibits the proliferation of human EOC cells both in vitro and in vivo in an orthotopic EOC mouse model
21816908Mechanistically, Wnt5a antagonizes canonical Wnt/beta-catenin signaling and induces cellular senescence by activating the histone repressor A/promyelocytic leukemia senescence pathway
21816908In summary, we show that loss of Wnt5a predicts poor outcome in EOC patients and Wnt5a suppresses the growth of EOC cells by triggering cellular senescence
21816908We suggest that strategies to drive senescence in EOC cells by reconstituting Wnt5a signaling may offer an effective new strategy for EOC therapy
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