HCSGD entry for WNT2

1. General information

Official gene symbolWNT2
Entrez ID7472
Gene full namewingless-type MMTV integration site family member 2
Other gene symbolsINT1L1 IRP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001938Positive regulation of endothelial cell proliferationIEAbiological_process
GO:0002053Positive regulation of mesenchymal cell proliferationIEAbiological_process
GO:0002088Lens development in camera-type eyeISSbiological_process
GO:0005102Receptor bindingIEAmolecular_function
GO:0005109Frizzled bindingIPImolecular_function
GO:0005125Cytokine activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionNAS TAScellular_component
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005615Extracellular spaceIBAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0007267Cell-cell signalingIDAbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0010469Regulation of receptor activityICbiological_process
GO:0016055Wnt signaling pathwayIDA IEAbiological_process
GO:0030182Neuron differentiationIBA ISSbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0031012Extracellular matrixIDAcellular_component
GO:0045165Cell fate commitmentIBAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048018Receptor agonist activityICmolecular_function
GO:0048146Positive regulation of fibroblast proliferationIMPbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0055009Atrial cardiac muscle tissue morphogenesisIEAbiological_process
GO:0060045Positive regulation of cardiac muscle cell proliferationIEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIDAbiological_process
GO:0060317Cardiac epithelial to mesenchymal transitionIEAbiological_process
GO:0060492Lung inductionIEAbiological_process
GO:0060501Positive regulation of epithelial cell proliferation involved in lung morphogenesisIEAbiological_process
GO:0060716Labyrinthine layer blood vessel developmentIEAbiological_process
GO:0061072Iris morphogenesisISSbiological_process
GO:0061180Mammary gland epithelium developmentIEPbiological_process
GO:0071300Cellular response to retinoic acidISSbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIEPbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIMPbiological_process
GO:2000273Positive regulation of receptor activityICbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02515151780.03223411720.37282093420.3377524682

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0430869623
GSE13712_SHEARDown-0.2430500585
GSE13712_STATICDown-0.0632267623
GSE19018Down-2.1785658756
GSE19899_A1Up0.0575888127
GSE19899_A2Down-1.1427797998
PubMed_21979375_A1Down-0.0707728144
PubMed_21979375_A2Down-0.4843776510
GSE35957Up2.8969879413
GSE36640Down-1.2234303261
GSE54402Down-1.1062751940
GSE9593Up0.0119856592
GSE43922Up0.0173793961
GSE24585Up0.3913585744
GSE37065Up0.4940745948
GSE28863_A1Up2.6603456486
GSE28863_A2Up1.1829821699
GSE28863_A3Down-0.2122024808
GSE28863_A4Up0.1237205070
GSE48662Down-0.0898806284

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-181a-5pMIMAT0000256MIRT025070MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20569479Recent studies in human fibroblasts have defined a cell signaling pathway that is initiated by repression of a specific Wnt ligand, Wnt2
17643369Here we show that expression of the canonical Wnt2 ligand and downstream canonical Wnt signals are repressed in senescent human cells
17643369Repression of Wnt2 occurs early in senescence and independently of the pRB and p53 tumor suppressor proteins and drives relocalization of HIRA to PML bodies, formation of SAHF and senescence, likely through GSK3beta-mediated phosphorylation of HIRA
15136151Genes upregulated in Shh(-/-);Gli3(-/-) relative to Shh(-/-) lung include Wnt2 and, surprisingly, Foxf1 whose expression has been reported to be Shh-dependent
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