HCSGD entry for WHSC1
1. General information
| Official gene symbol | WHSC1 |
|---|---|
| Entrez ID | 7468 |
| Gene full name | Wolf-Hirschhorn syndrome candidate 1 |
| Other gene symbols | MMSET NSD2 REIIBP TRX5 WHS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0003149 | Membranous septum morphogenesis | IEA | biological_process |
| GO:0003289 | Atrial septum primum morphogenesis | IEA | biological_process |
| GO:0003290 | Atrial septum secundum morphogenesis | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005694 | Chromosome | IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0009653 | Anatomical structure morphogenesis | TAS | biological_process |
| GO:0018024 | Histone-lysine N-methyltransferase activity | IEA | molecular_function |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0060348 | Bone development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9901665248 | 0.0020721667 | 0.9999902473 | 0.0869880383 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4719088596 |
| GSE13712_SHEAR | Down | -0.2253963114 |
| GSE13712_STATIC | Down | -0.2947813094 |
| GSE19018 | Up | 0.0680224103 |
| GSE19899_A1 | Down | -0.5712896580 |
| GSE19899_A2 | Down | -1.5984865810 |
| PubMed_21979375_A1 | Down | -0.8500059296 |
| PubMed_21979375_A2 | Down | -2.1521483248 |
| GSE35957 | Down | -1.4972892248 |
| GSE36640 | Down | -2.4338773279 |
| GSE54402 | Down | -0.1055051798 |
| GSE9593 | Down | -0.7925157239 |
| GSE43922 | Down | -0.5402221331 |
| GSE24585 | Down | -0.2039472263 |
| GSE37065 | Down | -0.0915969391 |
| GSE28863_A1 | Up | 0.1939203461 |
| GSE28863_A2 | Up | 0.3212416155 |
| GSE28863_A3 | Down | -0.1087150496 |
| GSE28863_A4 | Down | -0.0088896097 |
| GSE48662 | Down | -0.3711131970 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016397 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016397 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024330 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026347 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030752 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040294 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042600 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-339-5p | MIMAT0000764 | MIRT042763 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043035 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049392 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
