HCSGD entry for WFS1
1. General information
| Official gene symbol | WFS1 |
|---|---|
| Entrez ID | 7466 |
| Gene full name | Wolfram syndrome 1 (wolframin) |
| Other gene symbols | WFRS WFS WFSL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001822 | Kidney development | IMP | biological_process |
| GO:0003091 | Renal water homeostasis | IMP | biological_process |
| GO:0005215 | Transporter activity | ISS | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IEA ISS | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006983 | ER overload response | IC TAS | biological_process |
| GO:0006987 | Activation of signaling protein activity involved in unfolded protein response | TAS | biological_process |
| GO:0007601 | Visual perception | IMP | biological_process |
| GO:0007605 | Sensory perception of sound | IMP | biological_process |
| GO:0022417 | Protein maturation by protein folding | IC | biological_process |
| GO:0030176 | Integral component of endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0030425 | Dendrite | ISS | cellular_component |
| GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process | ISS | biological_process |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | ISS TAS | biological_process |
| GO:0031398 | Positive regulation of protein ubiquitination | ISS | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | ISS | molecular_function |
| GO:0032469 | Endoplasmic reticulum calcium ion homeostasis | IDA | biological_process |
| GO:0033613 | Activating transcription factor binding | ISS | molecular_function |
| GO:0034976 | Response to endoplasmic reticulum stress | IDA | biological_process |
| GO:0042048 | Olfactory behavior | IEA | biological_process |
| GO:0042593 | Glucose homeostasis | IMP | biological_process |
| GO:0043069 | Negative regulation of programmed cell death | IMP | biological_process |
| GO:0043433 | Negative regulation of sequence-specific DNA binding transcription factor activity | ISS | biological_process |
| GO:0043524 | Negative regulation of neuron apoptotic process | IMP | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045862 | Positive regulation of proteolysis | ISS | biological_process |
| GO:0045927 | Positive regulation of growth | ISS | biological_process |
| GO:0048306 | Calcium-dependent protein binding | IEA | molecular_function |
| GO:0050821 | Protein stabilization | ISS | biological_process |
| GO:0050877 | Neurological system process | IMP | biological_process |
| GO:0051117 | ATPase binding | IPI | molecular_function |
| GO:0051247 | Positive regulation of protein metabolic process | IDA | biological_process |
| GO:0051928 | Positive regulation of calcium ion transport | IDA | biological_process |
| GO:0055074 | Calcium ion homeostasis | IDA IEA | biological_process |
| GO:0070845 | Polyubiquitinated misfolded protein transport | ISS | biological_process |
| GO:1902236 | Negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | ISS | biological_process |
| GO:2000675 | Negative regulation of type B pancreatic cell apoptotic process | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0939816914 | 0.1153802629 | 0.6426843596 | 0.6505835261 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2599279223 |
| GSE13712_SHEAR | Down | -0.6527417209 |
| GSE13712_STATIC | Down | -0.7844269244 |
| GSE19018 | Up | 0.6596783926 |
| GSE19899_A1 | Down | -1.1651189183 |
| GSE19899_A2 | Down | -0.1323222854 |
| PubMed_21979375_A1 | Up | 0.0957851958 |
| PubMed_21979375_A2 | Up | 0.6185859539 |
| GSE35957 | Up | 0.4980577854 |
| GSE36640 | Up | 1.3429598708 |
| GSE54402 | Down | -0.5699758325 |
| GSE9593 | Up | 0.2462026363 |
| GSE43922 | Down | -0.5124260502 |
| GSE24585 | Down | -0.1415960675 |
| GSE37065 | Up | 0.0130460748 |
| GSE28863_A1 | Up | 0.0261872953 |
| GSE28863_A2 | Up | 0.2308422783 |
| GSE28863_A3 | Up | 0.1557719946 |
| GSE28863_A4 | Down | -0.2539573696 |
| GSE48662 | Up | 0.7392360544 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT000164 | Quantitative proteomic approach | Functional MTI (Weak) | 19253296 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025906 | Microarray | Functional MTI (Weak) | 19073608 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
