HCSGD entry for WARS
1. General information
| Official gene symbol | WARS |
|---|---|
| Entrez ID | 7453 |
| Gene full name | tryptophanyl-tRNA synthetase |
| Other gene symbols | GAMMA-2 IFI53 IFP53 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0004812 | Aminoacyl-tRNA ligase activity | IEA | molecular_function |
| GO:0004830 | Tryptophan-tRNA ligase activity | IEA NAS TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0006418 | TRNA aminoacylation for protein translation | IEA TAS | biological_process |
| GO:0006436 | Tryptophanyl-tRNA aminoacylation | IEA NAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0045765 | Regulation of angiogenesis | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1273767372 | 0.1179001330 | 0.7267901799 | 0.6592454970 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4401429210 |
| GSE13712_SHEAR | Up | 0.2595864833 |
| GSE13712_STATIC | Up | 0.2220177880 |
| GSE19018 | Up | 0.1883481544 |
| GSE19899_A1 | Down | -0.4651677090 |
| GSE19899_A2 | Down | -0.6827233857 |
| PubMed_21979375_A1 | Up | 0.4570265814 |
| PubMed_21979375_A2 | Down | -0.7530445417 |
| GSE35957 | Down | -0.7652349502 |
| GSE36640 | Up | 0.3282733454 |
| GSE54402 | Down | -0.7267281486 |
| GSE9593 | Up | 0.7051383974 |
| GSE43922 | Down | -0.0153154485 |
| GSE24585 | Up | 0.0112281641 |
| GSE37065 | Up | 0.3930294368 |
| GSE28863_A1 | Up | 0.4090021696 |
| GSE28863_A2 | Down | -0.5880518390 |
| GSE28863_A3 | Down | -0.4250309326 |
| GSE28863_A4 | Up | 0.1915027120 |
| GSE48662 | Up | 0.5299058947 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030141 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031943 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040542 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044483 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
