HCSGD entry for VTN

1. General information

Official gene symbolVTN
Entrez ID7448
Gene full namevitronectin
Other gene symbolsV75 VN VNT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005044Scavenger receptor activityIEAmolecular_function
GO:0005178Integrin bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionNAS TAScellular_component
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0006955Immune responseIEA TASbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007160Cell-matrix adhesionIDA IEAbiological_process
GO:0008201Heparin bindingIEAmolecular_function
GO:0010811Positive regulation of cell-substrate adhesionIEAbiological_process
GO:0010951Negative regulation of endopeptidase activityIDAbiological_process
GO:0014911Positive regulation of smooth muscle cell migrationIDAbiological_process
GO:0030195Negative regulation of blood coagulationICbiological_process
GO:0030198Extracellular matrix organizationIEA TASbiological_process
GO:0030247Polysaccharide bindingIEAmolecular_function
GO:0030449Regulation of complement activationTASbiological_process
GO:0030949Positive regulation of vascular endothelial growth factor receptor signaling pathwayTASbiological_process
GO:0031012Extracellular matrixIDA ISScellular_component
GO:0032092Positive regulation of protein bindingIDAbiological_process
GO:0033627Cell adhesion mediated by integrinIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0048260Positive regulation of receptor-mediated endocytosisIDAbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0050840Extracellular matrix bindingIEAmolecular_function
GO:0061302Smooth muscle cell-matrix adhesionIDAbiological_process
GO:0071062Alphav-beta3 integrin-vitronectin complexTAScellular_component
GO:0090303Positive regulation of wound healingICbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.41116315870.98278277040.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.0502575074
GSE28863_A2Up0.0717824744
GSE28863_A3Up0.2226831735
GSE28863_A4Up0.0999675107
GSE48662Up0.0513734129

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AbciximabDB00054 BTD00041 | BIOD00041

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018592MicroarrayFunctional MTI (Weak)18185580
hsa-miR-26b-5pMIMAT0000083MIRT029971MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23957394The pro-senescence effect of mutant collagen was blocked by vitronectin, a ligand for alphavss3 integrin that is presented by denatured but not native collagen
8780395Ingestion of apoptotic neutrophils by human monocyte-derived macrophages (M phi s) was found to be mediated by adhesive interactions between thrombospondin and the M phi alpha v beta 3 vitronectin receptor integrin and M phi CD36
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