HCSGD entry for VRK2
1. General information
| Official gene symbol | VRK2 |
|---|---|
| Entrez ID | 7444 |
| Gene full name | vaccinia related kinase 2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016772 | Transferase activity, transferring phosphorus-containing groups | IEA | molecular_function |
| GO:0031966 | Mitochondrial membrane | IDA | cellular_component |
| GO:0034599 | Cellular response to oxidative stress | IMP | biological_process |
| GO:0043408 | Regulation of MAPK cascade | IMP | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
| GO:2000659 | Regulation of interleukin-1-mediated signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4073369249 | 0.1949865089 | 0.9999902473 | 0.8553733167 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4177233856 |
| GSE13712_SHEAR | Up | 0.1880930017 |
| GSE13712_STATIC | Up | 0.4455182714 |
| GSE19018 | Down | -0.3925328442 |
| GSE19899_A1 | Down | -0.1403533188 |
| GSE19899_A2 | Up | 0.1286141387 |
| PubMed_21979375_A1 | Up | 0.4935761348 |
| PubMed_21979375_A2 | Up | 0.1997531816 |
| GSE35957 | Down | -0.2880354466 |
| GSE36640 | Down | -0.6036147906 |
| GSE54402 | Up | 0.2394303226 |
| GSE9593 | Down | -0.1743703359 |
| GSE43922 | Down | -0.0016289620 |
| GSE24585 | Down | -0.2891263945 |
| GSE37065 | Up | 0.3402441547 |
| GSE28863_A1 | Down | -0.3393844656 |
| GSE28863_A2 | Up | 0.2518944042 |
| GSE28863_A3 | Down | -0.4637429754 |
| GSE28863_A4 | Down | -0.2084919374 |
| GSE48662 | - | - |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
