HCSGD entry for EZR

1. General information

Official gene symbolEZR
Entrez ID7430
Gene full nameezrin
Other gene symbolsCVIL CVL VIL2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001726RuffleIDAcellular_component
GO:0001931UropodIEAcellular_component
GO:0003779Actin bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0005884Actin filamentIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005902MicrovillusIDAcellular_component
GO:0005925Focal adhesionIDAcellular_component
GO:0007016Cytoskeletal anchoring at plasma membraneNASbiological_process
GO:0007159Leukocyte cell-cell adhesionIEPbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008360Regulation of cell shapeIEAbiological_process
GO:0015629Actin cytoskeletonIDAcellular_component
GO:0016323Basolateral plasma membraneISScellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0019898Extrinsic component of membraneIDA IEAcellular_component
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0022614Membrane to membrane dockingIEPbiological_process
GO:0030175FilopodiumIDAcellular_component
GO:0030315T-tubuleIEAcellular_component
GO:0030855Epithelial cell differentiationIEAbiological_process
GO:0030863Cortical cytoskeletonTAScellular_component
GO:0031528Microvillus membraneIEAcellular_component
GO:0031623Receptor internalizationIEAbiological_process
GO:0032587Ruffle membraneIEAcellular_component
GO:0035088Establishment or maintenance of apical/basal cell polarityIEAbiological_process
GO:0044297Cell bodyIEAcellular_component
GO:0044393MicrospikeIEAcellular_component
GO:0045121Membrane raftIEAcellular_component
GO:0045177Apical part of cellIDAcellular_component
GO:0046847Filopodium assemblyIEAbiological_process
GO:0050839Cell adhesion molecule bindingIPImolecular_function
GO:0051015Actin filament bindingIDAmolecular_function
GO:0051017Actin filament bundle assemblyIDAbiological_process
GO:0051286Cell tipIEAcellular_component
GO:0097449Astrocyte projectionIEAcellular_component
GO:0097454Schwann cell microvillusIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.98538643290.00167920290.99999024730.0786605684

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2677828065
GSE13712_SHEARUp1.0353690521
GSE13712_STATICUp0.4740407546
GSE19018Down-0.0388769790
GSE19899_A1Down-0.8561131595
GSE19899_A2Down-1.6554233966
PubMed_21979375_A1Down-1.1972812310
PubMed_21979375_A2Down-2.9471366390
GSE35957Down-1.5416382372
GSE36640Down-1.0021575703
GSE54402Down-1.3682151985
GSE9593Down-0.1989546758
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.6443493500

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-183-5pMIMAT0000261MIRT004349Luciferase reporter assayFunctional MTI18840437
hsa-miR-204-5pMIMAT0000265MIRT005825Immunoblot//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI21282569
hsa-miR-204-5pMIMAT0000265MIRT005825Immunoblot//Luciferase reporter assayFunctional MTI21416062
hsa-miR-18a-5pMIMAT0000072MIRT031338SequencingFunctional MTI (Weak)20371350
hsa-miR-1180-3pMIMAT0005825MIRT035925CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040344CLASHFunctional MTI (Weak)23622248
hsa-miR-328-3pMIMAT0000752MIRT043797CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT045001CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045629CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046802CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049846CLASHFunctional MTI (Weak)23622248
hsa-miR-25-3pMIMAT0000081MIRT050361CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

16510591Phosphorylation of ezrin by cyclin-dependent kinase 5 induces the release of Rho GDP dissociation inhibitor to inhibit Rac1 activity in senescent cells
16510591Here, we show that pRb-induced senescent SAOS-2 cells and senescent human diploid fibroblasts are accompanied by increased phosphorylation of ezrin at T235 by cyclin-dependent kinase 5 and consequent dissociation of Rho GDP dissociation inhibitor (Rho-GDI) from an ezrin/Rho-GDI complex
14504464We have recently discovered that expression of active pRb induces expression and altered localization of the ERM family member ezrin, an actin-binding protein involved in membrane-cytoskeletal signaling
12769842Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype
12769842Here we show that senescence is accompanied by increased expression and altered localization of ezrin, an actin binding protein involved in membrane-cytoskeletal signaling
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