HCSGD entry for VDR

1. General information

Official gene symbolVDR
Entrez ID7421
Gene full namevitamin D (1,25- dihydroxyvitamin D3) receptor
Other gene symbolsNR1I1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000902Cell morphogenesisIMPbiological_process
GO:0001501Skeletal system developmentIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0004879Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006816Calcium ion transportIEAbiological_process
GO:0006874Cellular calcium ion homeostasisIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007595LactationIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0008434Calcitriol receptor activityIDA IEAmolecular_function
GO:0009887Organ morphogenesisIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010628Positive regulation of gene expressionIMPbiological_process
GO:0010839Negative regulation of keratinocyte proliferationIMPbiological_process
GO:0010980Positive regulation of vitamin D 24-hydroxylase activityIDAbiological_process
GO:0038183Bile acid signaling pathwayIDAbiological_process
GO:0038186Lithocholic acid receptor activityIDAmolecular_function
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045618Positive regulation of keratinocyte differentiationIMPbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0046697DecidualizationIEPbiological_process
GO:0046965Retinoid X receptor bindingIPImolecular_function
GO:0050892Intestinal absorptionIEAbiological_process
GO:0060058Positive regulation of apoptotic process involved in mammary gland involutionIEAbiological_process
GO:0060558Regulation of calcidiol 1-monooxygenase activityIEA ISSbiological_process
GO:0060745Mammary gland branching involved in pregnancyIEAbiological_process
GO:0070561Vitamin D receptor signaling pathwayIDAbiological_process
GO:0070644Vitamin D response element bindingIDAmolecular_function
GO:1902098Calcitriol bindingIDAmolecular_function
GO:1902121Lithocholic acid bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02365510430.89649618940.36517653961.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0594869819
GSE13712_SHEARDown-0.1336839347
GSE13712_STATICUp0.1358415197
GSE19018Down-0.0622394882
GSE19899_A1Up0.2021470823
GSE19899_A2Up0.5918127316
PubMed_21979375_A1Down-0.2381477136
PubMed_21979375_A2Up1.0942174999
GSE35957Up0.3810774112
GSE36640Up0.7251843703
GSE54402Up0.6361412881
GSE9593Up0.4492166067
GSE43922Up0.2476273341
GSE24585Up0.1034067400
GSE37065Down-0.4147602176
GSE28863_A1Down-0.0058346961
GSE28863_A2Up0.2906644962
GSE28863_A3Up0.4926113660
GSE28863_A4Down-0.4041513283
GSE48662Up0.2739175916

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ParicalcitolDB00910 APRD01165
DihydrotachysterolDB01070 APRD00143
CalcipotriolDB02300 EXPT02131
1-alpha, 25-dihydroxyl-20-epi-22-oxa-24, 26 ,27-trihomovitamin D3DB03451 EXPT01970
SeocalcitolDB04258 EXPT01322
InecalcitolDB04796 -
CTA018DB05024 -
EldecalcitolDB05295 -
DoxercalciferolDB06410 -
(1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diolDB07530 -
5-{2-[1-(1-METHYL-PROPYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-2-METHYLENE-CYCLOHEXANE-1,3-DIOLDB08696 -
1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)DB08742 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125b-5pMIMAT0000423MIRT001197Luciferase reporter assay//Western blotFunctional MTI19437538
hsa-let-7a-5pMIMAT0000062MIRT002080Luciferase reporter assayNon-Functional MTI17890240
hsa-miR-27b-3pMIMAT0000419MIRT006509Immunoblot//Luciferase reporter assayFunctional MTI19581388
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25392765Of note, CD8 T cells have the highest levels of the vitamin D receptor compared with other major immune cells
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