HCSGD entry for VCP

1. General information

Official gene symbolVCP
Entrez ID7415
Gene full namevalosin containing protein
Other gene symbolsALS14 IBMPFD TERA p97
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000502Proteasome complexIDAcellular_component
GO:0005102Receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDA TAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005783Endoplasmic reticulumIDA IEAcellular_component
GO:0005811Lipid particleIDAcellular_component
GO:0005829CytosolIDA IEAcellular_component
GO:0006281DNA repairNASbiological_process
GO:0006302Double-strand break repairIDAbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0006888ER to Golgi vesicle-mediated transportIEAbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIEA ISSbiological_process
GO:0006974Cellular response to DNA damage stimulusIDAbiological_process
GO:0008289Lipid bindingIEAmolecular_function
GO:0016567Protein ubiquitinationIDA NASbiological_process
GO:0016887ATPase activityIEA TASmolecular_function
GO:0018279Protein N-linked glycosylation via asparagineIMPbiological_process
GO:0019903Protein phosphatase bindingIPImolecular_function
GO:0019904Protein domain specific bindingIPImolecular_function
GO:0019985Translesion synthesisIMPbiological_process
GO:0030433ER-associated ubiquitin-dependent protein catabolic processIMP TASbiological_process
GO:0030968Endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0030970Retrograde protein transport, ER to cytosolIDAbiological_process
GO:0031334Positive regulation of protein complex assemblyIDAbiological_process
GO:0031593Polyubiquitin bindingIDA IEAmolecular_function
GO:0032403Protein complex bindingIEAmolecular_function
GO:0032436Positive regulation of proteasomal ubiquitin-dependent protein catabolic processIDA IEAbiological_process
GO:0035861Site of double-strand breakIDAcellular_component
GO:0042802Identical protein bindingIEAmolecular_function
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processNASbiological_process
GO:0043231Intracellular membrane-bounded organelleISScellular_component
GO:0043234Protein complexIEAcellular_component
GO:0043531ADP bindingIEAmolecular_function
GO:0045184Establishment of protein localizationTASbiological_process
GO:0045732Positive regulation of protein catabolic processIDAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0070842Aggresome assemblyIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48761730560.56823749480.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2455909454
GSE13712_SHEARUp0.1393982857
GSE13712_STATICUp0.1705093593
GSE19018Down-0.0694215022
GSE19899_A1Down-0.2461031442
GSE19899_A2Up0.0322208130
PubMed_21979375_A1Down-0.0277219360
PubMed_21979375_A2Down-0.1763375447
GSE35957Up0.0772678228
GSE36640Up0.0525856403
GSE54402Up0.4953130388
GSE9593Down-0.0673842025
GSE43922Down-0.0494835398
GSE24585Up0.0110673517
GSE37065Down-0.0254950047
GSE28863_A1Up0.2458235682
GSE28863_A2Up0.1964019288
GSE28863_A3Down-0.5705035026
GSE28863_A4Up0.1472528438
GSE48662Down-0.3832188558

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Phosphoaminophosphonic Acid-Adenylate EsterDB04395 EXPT00524

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029447MicroarrayFunctional MTI (Weak)19088304
hsa-miR-1301-3pMIMAT0005797MIRT035997CLASHFunctional MTI (Weak)23622248
hsa-miR-1296-5pMIMAT0005794MIRT036129CLASHFunctional MTI (Weak)23622248
hsa-miR-935MIMAT0004978MIRT036672CLASHFunctional MTI (Weak)23622248
hsa-miR-361-3pMIMAT0004682MIRT038268CLASHFunctional MTI (Weak)23622248
hsa-miR-296-3pMIMAT0004679MIRT038367CLASHFunctional MTI (Weak)23622248
hsa-miR-361-5pMIMAT0000703MIRT044062CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046614CLASHFunctional MTI (Weak)23622248
hsa-miR-196a-5pMIMAT0000226MIRT048237CLASHFunctional MTI (Weak)23622248
hsa-miR-100-5pMIMAT0000098MIRT048477CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

17555746Recent findings demonstrate that specific depletion of individual chaperones, including various members of the Hsp70 family, small heat shock proteins, or VCP/p97, leads to activation of p53 pathway and subsequently triggers cellular senescence
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