HCSGD entry for KDM6A
1. General information
| Official gene symbol | KDM6A |
|---|---|
| Entrez ID | 7403 |
| Gene full name | lysine (K)-specific demethylase 6A |
| Other gene symbols | KABUK2 UTX bA386N14.2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IEA | molecular_function |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001843 | Neural tube closure | IEA | biological_process |
| GO:0003016 | Respiratory system process | IEA | biological_process |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0007507 | Heart development | IEA | biological_process |
| GO:0032525 | Somite rostral/caudal axis specification | IEA | biological_process |
| GO:0035097 | Histone methyltransferase complex | IDA | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048333 | Mesodermal cell differentiation | IEA | biological_process |
| GO:0048570 | Notochord morphogenesis | IEA | biological_process |
| GO:0051213 | Dioxygenase activity | IEA | molecular_function |
| GO:0051568 | Histone H3-K4 methylation | ISS | biological_process |
| GO:0060070 | Canonical Wnt signaling pathway | IEA | biological_process |
| GO:0071558 | Histone demethylase activity (H3-K27 specific) | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7794369287 | 0.3848436951 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0105360159 |
| GSE13712_SHEAR | Up | 0.2476782966 |
| GSE13712_STATIC | Up | 0.0418104404 |
| GSE19018 | Down | -0.3052855342 |
| GSE19899_A1 | Up | 0.0075599218 |
| GSE19899_A2 | Down | -0.3901057053 |
| PubMed_21979375_A1 | Up | 0.2776767838 |
| PubMed_21979375_A2 | Up | 0.0996708203 |
| GSE35957 | Down | -0.1726050147 |
| GSE36640 | Down | -0.1354531145 |
| GSE54402 | Up | 0.0135987623 |
| GSE9593 | Up | 0.0024549151 |
| GSE43922 | Down | -0.0817216872 |
| GSE24585 | Up | 0.3049437798 |
| GSE37065 | Up | 0.4324915843 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.4483609544 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27228653 | Induction of AD in mouse MSC of the C3H10T1/2 cell line was associated with an increase in the expression levels of BMI1, the genes of pRb family (RB, p130) and demethylase UTX, but not methyltransferase EZH2, whose products regulate the methylation levels of H3K27 |
| 27228653 | This is associated with a complete inhibition of the expression of adipogenic marker genes--PPARgamma2, ADIPOQ and a decrease in the expression of RB, p130, but not UTX |
| 24046371 | Finally, we note that HPV E7 expression creates a unique cellular vulnerability to small-molecule KDM6A/B inhibitors |
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