HCSGD entry for USP1
1. General information
| Official gene symbol | USP1 |
|---|---|
| Entrez ID | 7398 |
| Gene full name | ubiquitin specific peptidase 1 |
| Other gene symbols | UBP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004197 | Cysteine-type endopeptidase activity | TAS | molecular_function |
| GO:0004221 | Ubiquitin thiolesterase activity | IDA IEA | molecular_function |
| GO:0004843 | Ubiquitin-specific protease activity | IDA IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006282 | Regulation of DNA repair | IDA | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0009411 | Response to UV | IDA | biological_process |
| GO:0016579 | Protein deubiquitination | IDA | biological_process |
| GO:0035520 | Monoubiquitinated protein deubiquitination | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9955079632 | 0.0001994795 | 0.9999902473 | 0.0248226415 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6189349110 |
| GSE13712_SHEAR | Down | -0.3200934980 |
| GSE13712_STATIC | Down | -0.4575960807 |
| GSE19018 | Down | -0.2501418363 |
| GSE19899_A1 | Down | -1.7999426851 |
| GSE19899_A2 | Down | -3.2914337815 |
| PubMed_21979375_A1 | Down | -1.1879009545 |
| PubMed_21979375_A2 | Down | -3.1688221861 |
| GSE35957 | Down | -1.5625398479 |
| GSE36640 | Down | -3.0293351939 |
| GSE54402 | Down | -0.5177539809 |
| GSE9593 | Down | -0.6722127897 |
| GSE43922 | Down | -1.0816379334 |
| GSE24585 | Up | 0.1545675610 |
| GSE37065 | Down | -0.1035612900 |
| GSE28863_A1 | Down | -0.0143926862 |
| GSE28863_A2 | Up | 0.5659555622 |
| GSE28863_A3 | Down | -0.4755248189 |
| GSE28863_A4 | Down | -0.1774122206 |
| GSE48662 | Down | -0.7919691444 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT001747 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-375 | MIMAT0000728 | MIRT001747 | Reporter assay | Functional MTI | 15806104 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024602 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026803 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048468 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27160904 | Here, we show that OIS-associated transcriptional downregulation of deubiquitinating enzyme USP1 triggers and maintains a DNA damage checkpoint response with atypical DNA lesions that is dependent on functional FANCD2-FI-ATR-CHK1-p53-CDKN1A signaling |
| 27160904 | We find that a reduced USP1 level causes aberrant aggregation of its target FANCD2 concomitant with replication stress, accumulation, and colocalization of gamma-H2Ax and p53-binding protein 1 (53BP1) in large and unusual sparse DNA damage foci and an increased number of polyploid cells and cells arrested in G2/M, as well as a sensitization of senescence-bypassing cells to DNA interstrand crosslinking-mediated cell death |
| 27160904 | Our study identifies USP1 as a key senescence regulator controlling genomic integrity and a promising target for anti-cancer therapy |
| 23806336 | Taken together, Usp1 inhibition may be a useful strategy for upregulating TAp63 and preventing or treating squamous cell cancers in the general non-FA population |
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