HCSGD entry for USF2

1. General information

Official gene symbolUSF2
Entrez ID7392
Gene full nameupstream transcription factor 2, c-fos interacting
Other gene symbolsFIP bHLHb12
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000430Regulation of transcription from RNA polymerase II promoter by glucoseICbiological_process
GO:0000432Positive regulation of transcription from RNA polymerase II promoter by glucoseIMP ISSbiological_process
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIEAmolecular_function
GO:0003690Double-stranded DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006366Transcription from RNA polymerase II promoterIMPbiological_process
GO:0007595LactationIEAbiological_process
GO:0019086Late viral transcriptionICbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043425BHLH transcription factor bindingIPImolecular_function
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0055088Lipid homeostasisISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.66323608910.12191686870.99999024730.6700586358

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0998918032
GSE13712_SHEARDown-0.4120805041
GSE13712_STATICDown-0.1944630906
GSE19018Down-0.0627938291
GSE19899_A1Down-0.2614224750
GSE19899_A2Up0.4329992633
PubMed_21979375_A1Up0.3531855581
PubMed_21979375_A2Up0.4664166012
GSE35957Up0.0198005915
GSE36640Down-0.0580009072
GSE54402Up0.2377812574
GSE9593Up0.1109215682
GSE43922Up0.0101604143
GSE24585Down-0.0531297628
GSE37065Down-0.0730905076
GSE28863_A1Down-0.4564056657
GSE28863_A2Down-0.7461737992
GSE28863_A3Down-0.1814986968
GSE28863_A4Down-0.1212425160
GSE48662Up0.6555783213

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-10a-5pMIMAT0000253MIRT003896Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI19074828
hsa-miR-362-3pMIMAT0004683MIRT007350Western blotFunctional MTI23280316
hsa-miR-335-5pMIMAT0000765MIRT018532MicroarrayFunctional MTI (Weak)18185580
hsa-miR-339-5pMIMAT0000764MIRT042794CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044796CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-10a-5pMIMAT0000253NAhsa-miR-10a{Western blot}{overexpression by miRNA precursor transfection}19074828
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23268535Linkage analysis and candidate gene approaches have identified four genes that cause the inherited form of IPF, familial interstitial pneumonia (FIP)
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