HCSGD entry for USF1

1. General information

Official gene symbolUSF1
Entrez ID7391
Gene full nameupstream transcription factor 1
Other gene symbolsFCHL FCHL1 HYPLIP1 MLTF MLTFI UEF bHLHb11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000430Regulation of transcription from RNA polymerase II promoter by glucoseICbiological_process
GO:0000432Positive regulation of transcription from RNA polymerase II promoter by glucoseIEA IMP ISSbiological_process
GO:0001666Response to hypoxiaIMPbiological_process
GO:0003690Double-stranded DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIDA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005667Transcription factor complexIDAcellular_component
GO:0006006Glucose metabolic processIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0009411Response to UVIEA ISSbiological_process
GO:0019086Late viral transcriptionIDAbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0032869Cellular response to insulin stimulusIDAbiological_process
GO:0042593Glucose homeostasisTASbiological_process
GO:0042803Protein homodimerization activityIEA IPI TASmolecular_function
GO:0042826Histone deacetylase bindingIPImolecular_function
GO:0043425BHLH transcription factor bindingIPImolecular_function
GO:0043565Sequence-specific DNA bindingIDA IEAmolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0045990Carbon catabolite regulation of transcriptionTASbiological_process
GO:0046982Protein heterodimerization activityIEA IPImolecular_function
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0051918Negative regulation of fibrinolysisICbiological_process
GO:0055088Lipid homeostasisIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48004470190.30312364650.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0702661743
GSE13712_SHEARDown-0.3975949668
GSE13712_STATICDown-0.1620055553
GSE19018Up0.0221263907
GSE19899_A1Up0.0495062309
GSE19899_A2Up0.4622853593
PubMed_21979375_A1Up0.3527651703
PubMed_21979375_A2Up0.0240919060
GSE35957Up0.0975139015
GSE36640Up0.0347271963
GSE54402Up0.3220519470
GSE9593Down-0.0589483635
GSE43922Up0.3132407355
GSE24585Down-0.1924844142
GSE37065Up0.2529612217
GSE28863_A1Down-0.1926865973
GSE28863_A2Down-0.1756374474
GSE28863_A3Down-0.8588056779
GSE28863_A4Down-0.1703248516
GSE48662Up0.2271049407

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-93-3pMIMAT0004509MIRT038834CLASHFunctional MTI (Weak)23622248
hsa-miR-92b-3pMIMAT0003218MIRT040599CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045419CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.