HCSGD entry for UROS
1. General information
| Official gene symbol | UROS |
|---|---|
| Entrez ID | 7390 |
| Gene full name | uroporphyrinogen III synthase |
| Other gene symbols | UROIIIS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004852 | Uroporphyrinogen-III synthase activity | IDA IEA | molecular_function |
| GO:0005739 | Mitochondrion | ISS | cellular_component |
| GO:0005829 | Cytosol | NAS TAS | cellular_component |
| GO:0006778 | Porphyrin-containing compound metabolic process | TAS | biological_process |
| GO:0006780 | Uroporphyrinogen III biosynthetic process | IDA | biological_process |
| GO:0006782 | Protoporphyrinogen IX biosynthetic process | IEA | biological_process |
| GO:0006783 | Heme biosynthetic process | IC IDA TAS | biological_process |
| GO:0033014 | Tetrapyrrole biosynthetic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046677 | Response to antibiotic | IEA | biological_process |
| GO:0048037 | Cofactor binding | IEA | molecular_function |
| GO:0071243 | Cellular response to arsenic-containing substance | IEA | biological_process |
| GO:0071418 | Cellular response to amine stimulus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0634760040 | 0.6392044983 | 0.5431573147 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4248968742 |
| GSE13712_SHEAR | Up | 0.0894581004 |
| GSE13712_STATIC | Up | 0.3667607099 |
| GSE19018 | Up | 0.1675881547 |
| GSE19899_A1 | Up | 0.0059164816 |
| GSE19899_A2 | Up | 0.9100649742 |
| PubMed_21979375_A1 | Up | 0.7466495119 |
| PubMed_21979375_A2 | Up | 0.8510139054 |
| GSE35957 | Down | -0.2203501273 |
| GSE36640 | Up | 0.3634024792 |
| GSE54402 | Up | 0.3820894938 |
| GSE9593 | Up | 0.0943840057 |
| GSE43922 | Down | -0.3432234860 |
| GSE24585 | Down | -0.0134992190 |
| GSE37065 | Down | -0.2134580391 |
| GSE28863_A1 | Down | -0.1369311211 |
| GSE28863_A2 | Down | -0.2989432318 |
| GSE28863_A3 | Down | -0.4451993356 |
| GSE28863_A4 | Up | 0.1360879817 |
| GSE48662 | Up | 0.0479314893 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29b-2-5p | MIMAT0004515 | MIRT038712 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
