HCSGD entry for NR1H2
1. General information
| Official gene symbol | NR1H2 |
|---|---|
| Entrez ID | 7376 |
| Gene full name | nuclear receptor subfamily 1, group H, member 2 |
| Other gene symbols | LXR-b LXRB NER NER-I RIP15 UNR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0001133 | Sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA TAS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003707 | Steroid hormone receptor activity | IEA | molecular_function |
| GO:0004879 | Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010745 | Negative regulation of macrophage derived foam cell differentiation | IC | biological_process |
| GO:0010867 | Positive regulation of triglyceride biosynthetic process | IMP | biological_process |
| GO:0010875 | Positive regulation of cholesterol efflux | IEA IMP | biological_process |
| GO:0010884 | Positive regulation of lipid storage | IEA | biological_process |
| GO:0010887 | Negative regulation of cholesterol storage | IMP | biological_process |
| GO:0032270 | Positive regulation of cellular protein metabolic process | IMP | biological_process |
| GO:0032369 | Negative regulation of lipid transport | IMP | biological_process |
| GO:0032376 | Positive regulation of cholesterol transport | IDA | biological_process |
| GO:0042632 | Cholesterol homeostasis | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0044255 | Cellular lipid metabolic process | IEA | biological_process |
| GO:0045723 | Positive regulation of fatty acid biosynthetic process | IMP | biological_process |
| GO:0045861 | Negative regulation of proteolysis | IEA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA IEA IMP | biological_process |
| GO:0046965 | Retinoid X receptor binding | IEA | molecular_function |
| GO:0048384 | Retinoic acid receptor signaling pathway | IEA | biological_process |
| GO:0048550 | Negative regulation of pinocytosis | IMP | biological_process |
| GO:0051006 | Positive regulation of lipoprotein lipase activity | IMP | biological_process |
| GO:0060336 | Negative regulation of interferon-gamma-mediated signaling pathway | NAS | biological_process |
| GO:0090108 | Positive regulation of high-density lipoprotein particle assembly | IEA | biological_process |
| GO:0090187 | Positive regulation of pancreatic juice secretion | IEA | biological_process |
| GO:0090340 | Positive regulation of secretion of lysosomal enzymes | IEA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0411026861 | 0.7489458189 | 0.4543737085 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4284857658 |
| GSE13712_SHEAR | Down | -0.0780103713 |
| GSE13712_STATIC | Up | 0.5220213375 |
| GSE19018 | Up | 0.0741790539 |
| GSE19899_A1 | Down | -0.0663161705 |
| GSE19899_A2 | Up | 0.9384198989 |
| PubMed_21979375_A1 | Up | 0.3963519254 |
| PubMed_21979375_A2 | Up | 2.4688400975 |
| GSE35957 | Up | 0.1530051066 |
| GSE36640 | Up | 0.0076928947 |
| GSE54402 | Down | -0.1264139302 |
| GSE9593 | Up | 0.2079294046 |
| GSE43922 | Up | 0.2097975638 |
| GSE24585 | Down | -0.0049591545 |
| GSE37065 | Down | -0.1649110263 |
| GSE28863_A1 | Down | -0.1641050284 |
| GSE28863_A2 | Down | -0.3807604880 |
| GSE28863_A3 | Down | -0.2857776230 |
| GSE28863_A4 | Down | -0.1236932403 |
| GSE48662 | Up | 1.0258179458 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Entries Per Page
Displaying Page of
- Drugs
Name | Drug | Accession number |
|---|---|---|
| (3-{3-[[2-Chloro-3-(Trifluoromethyl)Benzyl](2,2-Diphenylethyl)Amino]Propoxy}Phenyl)Acetic Acid | DB03791 | EXPT00345 |
| Benzenesulfonyl | DB03848 | EXPT00732 |
| N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE | DB07080 | - |
| 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL | DB07082 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT025788 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040136 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24398515 | A series of experiments that used siRNAs indicated that LXRbeta mediates the prevention of endothelial cellular senescence, and that sterol regulatory element binding protein-1, which was up-regulated as a direct LXRbeta target gene, may act as a brake of endothelial cellular senescence |
| 15758148 | Nucleotide excision repair (NER) is an important mechanism for coping with a variety of DNA lesions |
| 15758148 | Little is known about NER activity in spermatogenic cells |
| 15758148 | In the present study, NER was measured in defined spermatogenic cell types, including premeiotic cells (A and B type spermatogonia), meiotic cells (pachytene spermatocytes), and postmeiotic haploid cells (round spermatids) and compared with NER in keratinocytes |
| 15758148 | Global genome repair and transcription-coupled repair subpathways of NER were examined |
| 15758148 | Overall, the data suggest cell type-specific NER activity during murine spermatogenesis, and our results have possible implications for germ cell aging |
| 10022922 | The xeroderma pigmentosum group G (XP-G) gene (XPG) encodes a structure-specific DNA endonuclease that functions in nucleotide excision repair (NER) |
| 10022922 | The known XPG protein function as the 3' nuclease in NER, however, cannot explain the development of CS in certain XP-G patients |
| 10022922 | Since XPA-deficient mice, which are totally defective in NER, do not show such symptoms, our data indicate that XPG performs an additional function(s) besides its role in NER |
Entries Per Page
Displaying Page of
