HCSGD entry for UGCG
1. General information
| Official gene symbol | UGCG |
|---|---|
| Entrez ID | 7357 |
| Gene full name | UDP-glucose ceramide glucosyltransferase |
| Other gene symbols | GCS GLCT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0006665 | Sphingolipid metabolic process | TAS | biological_process |
| GO:0006679 | Glucosylceramide biosynthetic process | TAS | biological_process |
| GO:0006687 | Glycosphingolipid metabolic process | TAS | biological_process |
| GO:0006688 | Glycosphingolipid biosynthetic process | TAS | biological_process |
| GO:0008120 | Ceramide glucosyltransferase activity | IEA | molecular_function |
| GO:0008544 | Epidermis development | TAS | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5172782379 | 0.0015663045 | 0.9999902473 | 0.0761726937 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.0976933207 |
| GSE13712_SHEAR | Up | 0.3030112192 |
| GSE13712_STATIC | Up | 0.2741929986 |
| GSE19018 | Up | 1.3403393010 |
| GSE19899_A1 | Down | -2.4948301971 |
| GSE19899_A2 | Down | -1.1140330022 |
| PubMed_21979375_A1 | Down | -2.2337813127 |
| PubMed_21979375_A2 | Down | -1.3995502682 |
| GSE35957 | Down | -0.0603989675 |
| GSE36640 | Up | 0.0293661221 |
| GSE54402 | Down | -1.4008246108 |
| GSE9593 | Up | 0.6349517174 |
| GSE43922 | Down | -1.3249708651 |
| GSE24585 | Up | 0.0474525599 |
| GSE37065 | Down | -0.3117051974 |
| GSE28863_A1 | Down | -0.6282058917 |
| GSE28863_A2 | Up | 0.2631687198 |
| GSE28863_A3 | Down | -0.2915005706 |
| GSE28863_A4 | Down | -0.0626870923 |
| GSE48662 | Down | -0.3417102835 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT019137 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-375 | MIMAT0000728 | MIRT020053 | Microarray | Functional MTI (Weak) | 20215506 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17928415 | Treatment of endothelial cells with d-threo-EtDOP4, an inhibitor of glucosylceramide synthase, inhibited apoptosis, but not the development of senescence |
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