HCSGD entry for SUMO1

1. General information

Official gene symbolSUMO1
Entrez ID7341
Gene full namesmall ubiquitin-like modifier 1
Other gene symbolsDAP1 GMP1 OFC10 PIC1 SENP2 SMT3 SMT3C SMT3H3 UBL1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005643Nuclear poreTAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006281DNA repairTASbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0016604Nuclear bodyIEAcellular_component
GO:0016605PML bodyIDAcellular_component
GO:0016607Nuclear speckIEAcellular_component
GO:0016925Protein sumoylationIDA TASbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0019789SUMO ligase activityIEAmolecular_function
GO:0030425DendriteIEAcellular_component
GO:0030578PML body organizationIEAbiological_process
GO:0031334Positive regulation of protein complex assemblyIDAbiological_process
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0031965Nuclear membraneIEAcellular_component
GO:0032436Positive regulation of proteasomal ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0032880Regulation of protein localizationTASbiological_process
GO:0043392Negative regulation of DNA bindingIMPbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIMPbiological_process
GO:0045202SynapseIEAcellular_component
GO:0045892Negative regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0060021Palate developmentIEA ISSbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060334Regulation of interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0090204Protein localization to nuclear poreIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.94399171760.26740896240.99999024730.9890710412

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1060695175
GSE13712_SHEARDown-0.0115612967
GSE13712_STATICDown-0.0901360669
GSE19018Up0.1574466785
GSE19899_A1Up0.2102507235
GSE19899_A2Down-0.0786063557
PubMed_21979375_A1Down-0.2402111037
PubMed_21979375_A2Down-0.2775908529
GSE35957Up0.0321627847
GSE36640Down-0.2684085929
GSE54402Down-0.0530350913
GSE9593Down-0.0426144835
GSE43922Up0.0489331137
GSE24585Up0.0474603139
GSE37065Down-0.2201748629
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.2807438776

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-877-3pMIMAT0004950MIRT036934CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26826302In NP cells hypoxia transiently increased the expression of SUMO-1, SUMO-2/3, SAE2, and UBC9, whereas SUMO-1 was elevated while SUMO-2/3, SAE1, SAE2, and UBC9 were reduced by low oxygen tensions in AF cells
23893515Here, we determined the genome-wide localization of SUMO1 and SUMO2/3, as well as of UBC9 (encoded by UBE2I) and PIASY (encoded by PIAS4), two markers for active sumoylation, along with Pol II and histone marks in proliferating versus senescent human fibroblasts together with gene expression profiling
21811608Our findings also point to new roles for Tpr in the regulation of SUMO-1 conjugation at the nuclear pore and directly confirm Tpr involvement in the nuclear export of NES-proteins
12370286In fibroblasts, APA-1 was modified by the ubiquitin-like protein SUMO-1, which increased APA-1 half-life, possibly by blocking ubiquitin-mediated degradation
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