HCSGD entry for UBE3A

1. General information

Official gene symbolUBE3A
Entrez ID7337
Gene full nameubiquitin protein ligase E3A
Other gene symbolsANCR AS E6-AP EPVE6AP HPVE6A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000502Proteasome complexIEAcellular_component
GO:0001541Ovarian follicle developmentIEAbiological_process
GO:0003713Transcription coactivator activityIEAmolecular_function
GO:0004842Ubiquitin-protein ligase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIBAcellular_component
GO:0005737CytoplasmIBAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0006508ProteolysisTASbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processTASbiological_process
GO:0007420Brain developmentTASbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIEAbiological_process
GO:0016032Viral processIEAbiological_process
GO:0030521Androgen receptor signaling pathwayIBAbiological_process
GO:0035037Sperm entryIEAbiological_process
GO:0042787Protein ubiquitination involved in ubiquitin-dependent protein catabolic processIBAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0060736Prostate gland growthIEAbiological_process
GO:0070936Protein K48-linked ubiquitinationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.81196887280.70431379890.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1190019855
GSE13712_SHEARUp0.0265482407
GSE13712_STATICDown-0.0893574556
GSE19018Down-0.0311273781
GSE19899_A1Up0.2565789813
GSE19899_A2Up0.0327804681
PubMed_21979375_A1Up0.3280135617
PubMed_21979375_A2Up0.0030203701
GSE35957Up0.0484922107
GSE36640Down-0.2171734743
GSE54402Up0.1337042796
GSE9593Down-0.0786968212
GSE43922Down-0.0347830379
GSE24585Down-0.0261609907
GSE37065Up0.0559126887
GSE28863_A1Down-0.0143010492
GSE28863_A2Down-0.0431018001
GSE28863_A3Up0.1293369177
GSE28863_A4Down-0.0667664969
GSE48662Down-0.0124223433

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT019860MicroarrayFunctional MTI (Weak)20215506
hsa-miR-24-3pMIMAT0000080MIRT030496MicroarrayFunctional MTI (Weak)19748357
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27142689The HR-HPV E6 can activate hTERT promoter by interacting with E6AP or other binding proteins and by stabilizing the interaction between hTERT and E6AP
27142689We have previously reported the interaction of GRIM-19 with 18E6 and E6AP to disrupt the E6/E6AP complex and increase the autoubiquitination of E6AP
22986523However, the specific stress conditions that are controlled by E6AP have not been defined
22986523Here, we describe a novel role for E6AP in the control of oxidative stress response
22986523Cells lacking E6AP expression have reduced capacity to accumulate ROS, and oxidative DNA damage, in response to 20% cell culture oxygen levels, treatment with hydrogen peroxide and expression of oncogenic RAS
22986523Consequently, cells with compromised E6AP have impaired senescent and apoptotic response to sub-lethal and lethal doses of oxidative stress, respectively
22986523In a xenograft model, downregulation of E6AP renders transplanted tumours refractory to growth-suppressive effects of hydrogen peroxide
22986523Our results provide the first demonstration that E6AP is an important regulator of ROS-mediated cellular senescence and cell death
22689861E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis
22689861A partial loss of E6AP attenuated Myc-induced B-cell lymphomagenesis
22689861B-cell lymphomas deficient for E6AP expressed elevated levels of PML and PML-nuclear bodies with a concomitant increase in markers of cellular senescence, including p21, H3K9me3, and p16
22689861Importantly, E6AP expression was elevated in approximately 60% of human Burkitt lymphomas, and down-regulation of E6AP in B-lymphoma cells restored PML expression with a concurrent induction of cellular senescence in these cells
21927031E6AP is required for replicative and oncogene-induced senescence in mouse embryo fibroblasts
21927031We therefore explored the role of E6AP in the cellular response to stress
21927031We found that mouse embryo fibroblasts (MEFs) lacking E6AP escape replicative senescence, as well as Ras-induced senescence associated with impaired markers
21927031Overall, our study implicates E6AP as an important regulator of the cellular response to stress, in particular through the regulation of replicative and oncogene-induced senescence
17898049For instance, E7 acts to increase p53 levels while E6 accelerates its rate of turnover through the binding of the cellular ubiquitin ligase E6AP
17898049In contrast, mutant forms of E6 that are unable to bind E6AP remain resistant to the effects of interferon, demonstrating that the absolute levels of p53 are not the major determinants of this activity
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