HCSGD entry for UBE2L3
1. General information
| Official gene symbol | UBE2L3 |
|---|---|
| Entrez ID | 7332 |
| Gene full name | ubiquitin-conjugating enzyme E2L 3 |
| Other gene symbols | E2-F1 L-UBC UBCH7 UbcM4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000151 | Ubiquitin ligase complex | TAS | cellular_component |
| GO:0000209 | Protein polyubiquitination | IDA | biological_process |
| GO:0003713 | Transcription coactivator activity | IDA | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA IMP TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IDA IMP | biological_process |
| GO:0006464 | Cellular protein modification process | TAS | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | TAS | biological_process |
| GO:0008283 | Cell proliferation | IMP | biological_process |
| GO:0016567 | Protein ubiquitination | IDA | biological_process |
| GO:0019899 | Enzyme binding | TAS | molecular_function |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0070979 | Protein K11-linked ubiquitination | IDA | biological_process |
| GO:0071383 | Cellular response to steroid hormone stimulus | IMP | biological_process |
| GO:0071385 | Cellular response to glucocorticoid stimulus | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9303262604 | 0.1924649747 | 0.9999902473 | 0.8509768430 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1528349164 |
| GSE13712_SHEAR | Down | -0.1605668706 |
| GSE13712_STATIC | Down | -0.1801838411 |
| GSE19018 | Down | -0.4210563062 |
| GSE19899_A1 | Down | -0.3990146787 |
| GSE19899_A2 | Up | 0.0768102419 |
| PubMed_21979375_A1 | Up | 0.3150180092 |
| PubMed_21979375_A2 | Down | -0.2459065944 |
| GSE35957 | Down | -0.0282659326 |
| GSE36640 | Down | -0.2459655171 |
| GSE54402 | Up | 0.0853769403 |
| GSE9593 | Up | 0.2597559839 |
| GSE43922 | Down | -0.0361680871 |
| GSE24585 | Down | -0.1081799108 |
| GSE37065 | Up | 0.0782435521 |
| GSE28863_A1 | Down | -0.0065081459 |
| GSE28863_A2 | Down | -0.0653685116 |
| GSE28863_A3 | Down | -0.1997685196 |
| GSE28863_A4 | Up | 0.1335159364 |
| GSE48662 | Down | -0.3545669007 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT023267 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038073 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048772 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
