HCSGD entry for UBE2I

1. General information

Official gene symbolUBE2I
Entrez ID7329
Gene full nameubiquitin-conjugating enzyme E2I
Other gene symbolsC358B7.1 P18 UBC9
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0000795Synaptonemal complexTAScellular_component
GO:0001650Fibrillar centerIEAcellular_component
GO:0004842Ubiquitin-protein ligase activityIEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006464Cellular protein modification processTASbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processTASbiological_process
GO:0007059Chromosome segregationIEAbiological_process
GO:0007067MitosisIEAbiological_process
GO:0008022Protein C-terminus bindingIEAmolecular_function
GO:0008134Transcription factor bindingIPImolecular_function
GO:0010469Regulation of receptor activityIEAbiological_process
GO:0016032Viral processIEAbiological_process
GO:0016604Nuclear bodyIEAcellular_component
GO:0016605PML bodyIDAcellular_component
GO:0016925Protein sumoylationIDA IEA TASbiological_process
GO:0019789SUMO ligase activityIDA IEAmolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0030425DendriteIEAcellular_component
GO:0033145Positive regulation of intracellular steroid hormone receptor signaling pathwayIEAbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0043398HLH domain bindingIEAmolecular_function
GO:0043425BHLH transcription factor bindingIEAmolecular_function
GO:0045202SynapseIEAcellular_component
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIEAbiological_process
GO:0071535RING-like zinc finger domain bindingIPImolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97913576230.15932584250.99999024730.7710445404

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0588287531
GSE13712_SHEARDown-0.3465420870
GSE13712_STATICDown-0.1984404323
GSE19018Down-0.1500561408
GSE19899_A1Down-0.1483091891
GSE19899_A2Down-0.0935434669
PubMed_21979375_A1Down-0.2311599968
PubMed_21979375_A2Down-0.5194782739
GSE35957Up0.0367264997
GSE36640Down-0.3856062057
GSE54402Down-0.0329718392
GSE9593Down-0.0393219336
GSE43922Up0.0432312980
GSE24585Down-0.3459434662
GSE37065Down-0.1098935109
GSE28863_A1Up0.0767386469
GSE28863_A2Up0.0484162796
GSE28863_A3Up0.0210678125
GSE28863_A4Up0.0969980494
GSE48662Down-0.1738756125

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30e-5pMIMAT0000692MIRT003339Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI19223510
hsa-miR-200c-3pMIMAT0000617MIRT005087qRT-PCR//Western blotNon-Functional MTI19223510
hsa-miR-188-5pMIMAT0000457MIRT005088qRT-PCR//Western blotNon-Functional MTI19223510
hsa-miR-30c-5pMIMAT0000244MIRT005090Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI19223510
hsa-miR-1MIMAT0000416MIRT023885ProteomicsFunctional MTI (Weak)18668040
hsa-let-7b-5pMIMAT0000063MIRT032401ProteomicsFunctional MTI (Weak)18668040
hsa-miR-324-5pMIMAT0000761MIRT043111CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-125b-5pMIMAT0000423NAhsa-miR-125b18056640
hsa-miR-30c-5pMIMAT00002442hsa-miR-30c{Western blot}{overexpression}19223510
hsa-miR-30c-5pMIMAT00002441hsa-miR-30c{Western blot}{overexpression}19223510
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26826302DESIGN: Expression of small ubiquitin-like modifier (SUMO) molecules, SUMO E1 activating enzymes SAE1 and SAE2, SUMO E2 conjugating enzyme UBC9, and de-sumoylation enzyme sentrin/SUMO-specific proteases (SENP)1 was immunolocalized in rat intervertebral disc (IVD) cells
26826302In NP cells hypoxia transiently increased the expression of SUMO-1, SUMO-2/3, SAE2, and UBC9, whereas SUMO-1 was elevated while SUMO-2/3, SAE1, SAE2, and UBC9 were reduced by low oxygen tensions in AF cells
23893515Here, we determined the genome-wide localization of SUMO1 and SUMO2/3, as well as of UBC9 (encoded by UBE2I) and PIASY (encoded by PIAS4), two markers for active sumoylation, along with Pol II and histone marks in proliferating versus senescent human fibroblasts together with gene expression profiling
19436740Recently, DRIL1 was found to interact with the SUMO-conjugating enzyme Ubc9, but the functional relevance of this association has not been assessed
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