HCSGD entry for C8A
1. General information
| Official gene symbol | C8A |
|---|---|
| Entrez ID | 731 |
| Gene full name | complement component 8, alpha polypeptide |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001848 | Complement binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005579 | Membrane attack complex | IDA | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0006956 | Complement activation | IDA | biological_process |
| GO:0006957 | Complement activation, alternative pathway | IEA | biological_process |
| GO:0006958 | Complement activation, classical pathway | IEA | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0019835 | Cytolysis | IEA | biological_process |
| GO:0030449 | Regulation of complement activation | TAS | biological_process |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5266623115 | 0.8087404506 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0134022742 |
| GSE13712_SHEAR | Down | -0.1426604223 |
| GSE13712_STATIC | Up | 0.0455398776 |
| GSE19018 | Down | -0.1994245992 |
| GSE19899_A1 | Up | 0.0393923110 |
| GSE19899_A2 | Up | 0.3948662158 |
| PubMed_21979375_A1 | Up | 0.9040483769 |
| PubMed_21979375_A2 | Down | -0.2308686959 |
| GSE35957 | Up | 0.1120177383 |
| GSE36640 | Down | -0.0804431739 |
| GSE54402 | Up | 0.1378507897 |
| GSE9593 | Down | -0.0266019344 |
| GSE43922 | Up | 0.0339170704 |
| GSE24585 | Up | 0.0039458935 |
| GSE37065 | Down | -0.0037102761 |
| GSE28863_A1 | Down | -0.0388433742 |
| GSE28863_A2 | Up | 0.0667609206 |
| GSE28863_A3 | Up | 0.1297498663 |
| GSE28863_A4 | Up | 0.1029990200 |
| GSE48662 | Down | -0.0363414964 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017718 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025047 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
