HCSGD entry for TYROBP
1. General information
| Official gene symbol | TYROBP |
|---|---|
| Entrez ID | 7305 |
| Gene full name | TYRO protein tyrosine kinase binding protein |
| Other gene symbols | DAP12 KARAP PLOSL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002281 | Macrophage activation involved in immune response | IEA | biological_process |
| GO:0002283 | Neutrophil activation involved in immune response | IEA | biological_process |
| GO:0005057 | Receptor signaling protein activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006968 | Cellular defense response | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007229 | Integrin-mediated signaling pathway | IEA | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0035556 | Intracellular signal transduction | TAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0050776 | Regulation of immune response | TAS | biological_process |
| GO:2001204 | Regulation of osteoclast development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6280281524 | 0.5772455644 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2430090622 |
| GSE13712_SHEAR | Down | -0.0051854644 |
| GSE13712_STATIC | Down | -0.0948076308 |
| GSE19018 | Down | -0.2221501712 |
| GSE19899_A1 | Down | -0.0006774340 |
| GSE19899_A2 | Down | -0.1985474107 |
| PubMed_21979375_A1 | Down | -0.2130481413 |
| PubMed_21979375_A2 | Down | -0.1283931449 |
| GSE35957 | Down | -0.4762369615 |
| GSE36640 | Up | 0.1651735199 |
| GSE54402 | Down | -0.0026980876 |
| GSE9593 | Down | -0.1145102224 |
| GSE43922 | Up | 0.0595974976 |
| GSE24585 | Up | 0.1119515252 |
| GSE37065 | Down | -0.0839057170 |
| GSE28863_A1 | Up | 0.1387994506 |
| GSE28863_A2 | Up | 0.1117312246 |
| GSE28863_A3 | Up | 0.2416455269 |
| GSE28863_A4 | Up | 0.0754978034 |
| GSE48662 | Up | 0.0725676017 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16461801 | The signaling pathways of these regulatory receptors are complex and dependent on the individual T cells, some of which express important adapter molecules such as DAP10 and DAP12 |
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