HCSGD entry for TYRO3

1. General information

Official gene symbolTYRO3
Entrez ID7301
Gene full nameTYRO3 protein tyrosine kinase
Other gene symbolsBYK Dtk RSE Sky Tif
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001779Natural killer cell differentiationIEAbiological_process
GO:0004713Protein tyrosine kinase activityIDA IEAmolecular_function
GO:0004714Transmembrane receptor protein tyrosine kinase activityNASmolecular_function
GO:0004716Receptor signaling protein tyrosine kinase activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusISScellular_component
GO:0005635Nuclear envelopeISScellular_component
GO:0005789Endoplasmic reticulum membraneISScellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0007155Cell adhesionNASbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0007283SpermatogenesisIEA ISSbiological_process
GO:0014065Phosphatidylinositol 3-kinase signalingNASbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0018108Peptidyl-tyrosine phosphorylationIDA NASbiological_process
GO:0021885Forebrain cell migrationIEA ISSbiological_process
GO:0023014Signal transduction by phosphorylationNASbiological_process
GO:0030168Platelet activationISSbiological_process
GO:0032940Secretion by cellIEA ISSbiological_process
GO:0034122Negative regulation of toll-like receptor signaling pathwayIEA ISSbiological_process
GO:0034446Substrate adhesion-dependent cell spreadingIEA ISSbiological_process
GO:0042698Ovulation cycleIEA ISSbiological_process
GO:0043277Apoptotic cell clearanceIEA ISSbiological_process
GO:0043491Protein kinase B signalingIEA ISSbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEA ISSbiological_process
GO:0043548Phosphatidylinositol 3-kinase bindingIPImolecular_function
GO:0045824Negative regulation of innate immune responseIEA ISSbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0050728Negative regulation of inflammatory responseIEA ISSbiological_process
GO:0051250Negative regulation of lymphocyte activationIEAbiological_process
GO:0060068Vagina developmentIEAbiological_process
GO:0070050Neuron cellular homeostasisIEA ISSbiological_process
GO:0070527Platelet aggregationIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.65768856810.23031523500.99999024730.9242456624

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0810594870
GSE13712_SHEARDown-0.2869017867
GSE13712_STATICUp0.0955682984
GSE19018Up0.0030558628
GSE19899_A1Down-0.0121018490
GSE19899_A2Down-0.2670374138
PubMed_21979375_A1Up0.1115793424
PubMed_21979375_A2Up0.1103366317
GSE35957Down-0.2554806457
GSE36640Up0.4036969926
GSE54402Down-0.0138097999
GSE9593Up0.1927850716
GSE43922Up0.0332391842
GSE24585Down-0.7137941309
GSE37065Down-0.0796594513
GSE28863_A1Down-0.0238213534
GSE28863_A2Up0.1833577159
GSE28863_A3Down-0.2140745637
GSE28863_A4Down-0.0854005418
GSE48662Down-0.0548327140

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.