HCSGD entry for TYK2
1. General information
| Official gene symbol | TYK2 |
|---|---|
| Entrez ID | 7297 |
| Gene full name | tyrosine kinase 2 |
| Other gene symbols | JTK1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | IEA TAS | molecular_function |
| GO:0004715 | Non-membrane spanning protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005131 | Growth hormone receptor binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | TAS | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0031702 | Type 1 angiotensin receptor binding | IEA | molecular_function |
| GO:0060337 | Type I interferon signaling pathway | TAS | biological_process |
| GO:0060338 | Regulation of type I interferon-mediated signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3435018806 | 0.7140870484 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2026224943 |
| GSE13712_SHEAR | Down | -0.0541522796 |
| GSE13712_STATIC | Up | 0.1478328101 |
| GSE19018 | Up | 0.2007224730 |
| GSE19899_A1 | Down | -0.1270180183 |
| GSE19899_A2 | Down | -0.0934319490 |
| PubMed_21979375_A1 | Up | 0.2070557994 |
| PubMed_21979375_A2 | Up | 0.2370471575 |
| GSE35957 | Down | -0.6393765119 |
| GSE36640 | Up | 0.0868287221 |
| GSE54402 | Up | 0.2921096359 |
| GSE9593 | Down | -0.4395969208 |
| GSE43922 | Up | 0.0324817351 |
| GSE24585 | Up | 0.2009332917 |
| GSE37065 | Down | -0.0601742872 |
| GSE28863_A1 | Up | 0.0405004082 |
| GSE28863_A2 | Up | 0.1266012817 |
| GSE28863_A3 | Down | -0.1299227474 |
| GSE28863_A4 | Down | -0.0554773574 |
| GSE48662 | Up | 0.5377265601 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| 2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE | DB04716 | - |
| 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | DB08183 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023017 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23897841 | Instead, the prompt inhibition of Janus kinase 2 (Jak2), tyrosine kinase 2 (Tyk2), and signal transducer and activator of transcription 3 (Stat3) activation was observed in cells undergoing senescence |
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