HCSGD entry for TTR
1. General information
| Official gene symbol | TTR |
|---|---|
| Entrez ID | 7276 |
| Gene full name | transthyretin |
| Other gene symbols | CTS CTS1 HsT2651 PALB TBPA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001523 | Retinoid metabolic process | TAS | biological_process |
| GO:0005179 | Hormone activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | NAS TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006810 | Transport | IEA | biological_process |
| GO:0007603 | Phototransduction, visible light | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0042562 | Hormone binding | IEA | molecular_function |
| GO:0042572 | Retinol metabolic process | IEA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4012147601 | 0.8972757570 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1298318519 |
| GSE13712_SHEAR | Up | 0.2760268136 |
| GSE13712_STATIC | Down | -0.0704160233 |
| GSE19018 | Up | 0.1899254028 |
| GSE19899_A1 | Up | 0.0935721354 |
| GSE19899_A2 | Down | -0.0194830784 |
| PubMed_21979375_A1 | Up | 0.1398096105 |
| PubMed_21979375_A2 | Down | -0.0716768188 |
| GSE35957 | Up | 0.2328602830 |
| GSE36640 | Up | 0.0492216636 |
| GSE54402 | Up | 0.0963812581 |
| GSE9593 | Down | -0.0026277506 |
| GSE43922 | Up | 0.0226251482 |
| GSE24585 | Up | 0.3110269741 |
| GSE37065 | Up | 0.1129267274 |
| GSE28863_A1 | Down | -0.1532263814 |
| GSE28863_A2 | Down | -0.0195369830 |
| GSE28863_A3 | Up | 0.1125934108 |
| GSE28863_A4 | Up | 0.0555705742 |
| GSE48662 | Up | 0.1271955597 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21307604 | The SB system containing the telomerase gene controlled by two chimeric transthyretin (TTR) gene promoters/enhancers, the human alcohol dehydrogenase gene promoter (ADHp), and the SV40 viral enhancer (SV40VE) was constructed in order to activate hepatocyte cell growth |
| 18177264 | Here, we review recent progress in our knowledge of the turnover and translation regulatory (TTR) mRNA-binding proteins (RBPs) that influence gene expression in response to oxidative damage |
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