HCSGD entry for TTN

1. General information

Official gene symbolTTN
Entrez ID7273
Gene full nametitin
Other gene symbolsCMD1G CMH9 CMPD4 EOMFC HMERF LGMD2J MYLK5 TMD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000794Condensed nuclear chromosomeIDAcellular_component
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0002020Protease bindingIPImolecular_function
GO:0002576Platelet degranulationTASbiological_process
GO:0003007Heart morphogenesisIEAbiological_process
GO:0003300Cardiac muscle hypertrophyIMPbiological_process
GO:0004674Protein serine/threonine kinase activityIDAmolecular_function
GO:0004713Protein tyrosine kinase activityIEAmolecular_function
GO:0005509Calcium ion bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIPI TASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005865Striated muscle thin filamentIDAcellular_component
GO:0006936Muscle contractionIEA NAS TASbiological_process
GO:0006941Striated muscle contractionTASbiological_process
GO:0007076Mitotic chromosome condensationIEPbiological_process
GO:0007512Adult heart developmentIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008307Structural constituent of muscleIMP TASmolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030018Z discIDA IEAcellular_component
GO:0030049Muscle filament slidingTASbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030240Skeletal muscle thin filament assemblyIMPbiological_process
GO:0030241Skeletal muscle myosin thick filament assemblyIMPbiological_process
GO:0031430M bandIDA IEAcellular_component
GO:0031433Telethonin bindingIPI ISSmolecular_function
GO:0031674I bandIDAcellular_component
GO:0035995Detection of muscle stretchTASbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042805Actinin bindingIDA IPImolecular_function
GO:0043056Forward locomotionIEAbiological_process
GO:0043621Protein self-associationIDAmolecular_function
GO:0045214Sarcomere organizationIEA IMPbiological_process
GO:0045859Regulation of protein kinase activityIMPbiological_process
GO:0048739Cardiac muscle fiber developmentIMPbiological_process
GO:0048769SarcomerogenesisIMPbiological_process
GO:0050790Regulation of catalytic activityIMPbiological_process
GO:0051015Actin filament bindingIDAmolecular_function
GO:0051371Muscle alpha-actinin bindingIPImolecular_function
GO:0051592Response to calcium ionIDAbiological_process
GO:0055003Cardiac myofibril assemblyIEA IMPbiological_process
GO:0055008Cardiac muscle tissue morphogenesisIMPbiological_process
GO:0060048Cardiac muscle contractionIMPbiological_process
GO:0097493Structural molecule activity conferring elasticityTASmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.81804597090.38999525470.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0398258616
GSE13712_SHEARUp0.0226317793
GSE13712_STATICUp0.0964431480
GSE19018Down-0.0712857791
GSE19899_A1Up0.0635280585
GSE19899_A2Up0.0675344913
PubMed_21979375_A1Up0.1902479653
PubMed_21979375_A2Up0.1881778740
GSE35957Up0.0737141407
GSE36640Up0.0563997606
GSE54402Down-0.0633466838
GSE9593Up0.0471973311
GSE43922Up0.0159187503
GSE24585Up0.1075932826
GSE37065Up0.1117241295
GSE28863_A1Up0.1453529672
GSE28863_A2Down-0.5828373015
GSE28863_A3Down-0.8358168527
GSE28863_A4Down-0.2081634539
GSE48662Down-0.0665049745

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26a-5pMIMAT0000082MIRT050140CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.