HCSGD entry for CAPN5
1. General information
| Official gene symbol | CAPN5 |
|---|---|
| Entrez ID | 726 |
| Gene full name | calpain 5 |
| Other gene symbols | HTRA3 nCL-3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004198 | Calcium-dependent cysteine-type endopeptidase activity | IEA | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0009986 | Cell surface | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0948697960 | 0.8904416170 | 0.6450704986 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1318333147 |
| GSE13712_SHEAR | Down | -0.6912343558 |
| GSE13712_STATIC | Down | -0.5144042849 |
| GSE19018 | Down | -0.0510130188 |
| GSE19899_A1 | Up | 0.0636063516 |
| GSE19899_A2 | Down | -0.0894441691 |
| PubMed_21979375_A1 | Up | 0.7519035209 |
| PubMed_21979375_A2 | Up | 0.5000644223 |
| GSE35957 | Down | -0.0931772740 |
| GSE36640 | Up | 0.2748442980 |
| GSE54402 | Up | 0.1855810923 |
| GSE9593 | Up | 0.4567283993 |
| GSE43922 | Up | 0.0290641730 |
| GSE24585 | Up | 0.1059818477 |
| GSE37065 | Up | 0.3692605102 |
| GSE28863_A1 | Up | 0.2510572239 |
| GSE28863_A2 | Up | 0.1247698506 |
| GSE28863_A3 | Up | 0.1946725741 |
| GSE28863_A4 | Up | 0.1619381037 |
| GSE48662 | Down | -0.2123824146 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24838245 | Calpain 5 is highly expressed in the central nervous system (CNS), carries dual nuclear localization signals, and is associated with nuclear promyelocytic leukemia protein bodies |
| 24838245 | Calpain 5 (CAPN5) is a non-classical member of the calpain family |
| 24838245 | TRA-3, an ortholog of CAPN5, has been shown to be involved in necrotic cell death in Caenorhabditis elegans |
| 24838245 | CAPN5 is expressed throughout the CNS, but its expression relative to other calpains and subcellular distribution has not been investigated previously |
| 24838245 | Based on relative mRNA levels, Capn5 is the second most highly expressed calpain in the rat CNS, with Capn2 mRNA being the most abundant |
| 24838245 | Unlike classical calpains, CAPN5 is a non-cytosolic protein localized to the nucleus and extra-nuclear locations |
| 24838245 | CAPN5 possesses two nuclear localization signals (NLS): an N-terminal monopartite NLS and a unique bipartite NLS closer to the C terminus |
| 24838245 | The C-terminal NLS contains a SUMO-interacting motif that contributes to nuclear localization, and mutation or deletion of both NLS renders CAPN5 exclusively cytosolic |
| 24838245 | Interestingly, CAPN5 is found in punctate domains associated with promyelocytic leukemia (PML) protein within the nucleus |
| 24838245 | The roles of nuclear CAPN5 remain to be determined |
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