HCSGD entry for TSC1
1. General information
| Official gene symbol | TSC1 |
|---|---|
| Entrez ID | 7248 |
| Gene full name | tuberous sclerosis 1 |
| Other gene symbols | LAM TSC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001822 | Kidney development | IEA | biological_process |
| GO:0001843 | Neural tube closure | IEA | biological_process |
| GO:0001952 | Regulation of cell-matrix adhesion | IMP | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0005884 | Actin filament | IDA | cellular_component |
| GO:0005938 | Cell cortex | IDA | cellular_component |
| GO:0006407 | RRNA export from nucleus | IMP | biological_process |
| GO:0006417 | Regulation of translation | IDA | biological_process |
| GO:0006813 | Potassium ion transport | IEA | biological_process |
| GO:0007050 | Cell cycle arrest | TAS | biological_process |
| GO:0007160 | Cell-matrix adhesion | IMP | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IMP | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0017148 | Negative regulation of translation | IMP | biological_process |
| GO:0021766 | Hippocampus development | IEA | biological_process |
| GO:0021987 | Cerebral cortex development | IEA | biological_process |
| GO:0030027 | Lamellipodium | IDA | cellular_component |
| GO:0030030 | Cell projection organization | IEA | biological_process |
| GO:0030426 | Growth cone | IEA | cellular_component |
| GO:0030695 | GTPase regulator activity | IEA | molecular_function |
| GO:0032007 | Negative regulation of TOR signaling | IMP | biological_process |
| GO:0032794 | GTPase activating protein binding | IEA | molecular_function |
| GO:0032862 | Activation of Rho GTPase activity | IDA | biological_process |
| GO:0032868 | Response to insulin | IDA | biological_process |
| GO:0033596 | TSC1-TSC2 complex | IDA | cellular_component |
| GO:0042552 | Myelination | IEA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IEA | cellular_component |
| GO:0043234 | Protein complex | IDA | cellular_component |
| GO:0043666 | Regulation of phosphoprotein phosphatase activity | IMP | biological_process |
| GO:0045792 | Negative regulation of cell size | IEA | biological_process |
| GO:0045859 | Regulation of protein kinase activity | IEA | biological_process |
| GO:0047485 | Protein N-terminus binding | IPI | molecular_function |
| GO:0050808 | Synapse organization | IEA | biological_process |
| GO:0050821 | Protein stabilization | IDA | biological_process |
| GO:0051087 | Chaperone binding | IPI | molecular_function |
| GO:0051291 | Protein heterooligomerization | IEA | biological_process |
| GO:0051492 | Regulation of stress fiber assembly | IDA | biological_process |
| GO:0051894 | Positive regulation of focal adhesion assembly | IDA | biological_process |
| GO:0055007 | Cardiac muscle cell differentiation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0179867786 | 0.9688805441 | 0.3285426787 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2951017913 |
| GSE13712_SHEAR | Up | 0.3051238551 |
| GSE13712_STATIC | Up | 0.1400664495 |
| GSE19018 | Up | 0.0292078196 |
| GSE19899_A1 | Up | 0.3128013596 |
| GSE19899_A2 | Up | 0.4992503358 |
| PubMed_21979375_A1 | Up | 0.2458099849 |
| PubMed_21979375_A2 | Up | 1.2275529944 |
| GSE35957 | Up | 0.1121686105 |
| GSE36640 | Up | 0.7040281854 |
| GSE54402 | Up | 0.4998085804 |
| GSE9593 | Up | 0.1582386298 |
| GSE43922 | Up | 0.0399924329 |
| GSE24585 | Up | 0.3877586422 |
| GSE37065 | Down | -0.0274514003 |
| GSE28863_A1 | Up | 0.4370276838 |
| GSE28863_A2 | Up | 0.3188295439 |
| GSE28863_A3 | Down | -0.6324057815 |
| GSE28863_A4 | Down | -0.0488151097 |
| GSE48662 | Down | -0.0402157228 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-32-5p | MIMAT0000090 | MIRT006630 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22431589 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT019220 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041346 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044265 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044756 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
