HCSGD entry for TRPS1
1. General information
| Official gene symbol | TRPS1 |
|---|---|
| Entrez ID | 7227 |
| Gene full name | trichorhinophalangeal syndrome I |
| Other gene symbols | GC79 LGCR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0001501 | Skeletal system development | TAS | biological_process |
| GO:0002062 | Chondrocyte differentiation | IEA | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006607 | NLS-bearing protein import into nucleus | TAS | biological_process |
| GO:0007178 | Transmembrane receptor protein serine/threonine kinase signaling pathway | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0031063 | Regulation of histone deacetylation | IEA | biological_process |
| GO:0032330 | Regulation of chondrocyte differentiation | IEA ISS | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:1902043 | Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0023245127 | 0.8106717222 | 0.1288493697 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2625327047 |
| GSE13712_SHEAR | Down | -0.1952825462 |
| GSE13712_STATIC | Up | 0.0671315123 |
| GSE19018 | Down | -0.4328279434 |
| GSE19899_A1 | Up | 0.6590021871 |
| GSE19899_A2 | Up | 1.4978107476 |
| PubMed_21979375_A1 | Up | 1.1244083204 |
| PubMed_21979375_A2 | Up | 1.2493852479 |
| GSE35957 | Down | -0.3801966127 |
| GSE36640 | Up | 0.7810393040 |
| GSE54402 | Up | 1.3478395580 |
| GSE9593 | Down | -0.1968428698 |
| GSE43922 | Up | 1.3219905722 |
| GSE24585 | Down | -0.5063963734 |
| GSE37065 | Up | 0.4312911676 |
| GSE28863_A1 | Up | 1.3137516114 |
| GSE28863_A2 | Up | 0.6838871437 |
| GSE28863_A3 | Down | -0.0224989525 |
| GSE28863_A4 | Up | 0.0933639165 |
| GSE48662 | Up | 0.2883541207 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-372-3p | MIMAT0000724 | MIRT000058 | Luciferase reporter assay//Microarray | Functional MTI | 19229866 |
| hsa-miR-302d-3p | MIMAT0000718 | MIRT000092 | Luciferase reporter assay//Microarray | Functional MTI | 19229866 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022984 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT023981 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030002 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-99b-5p | MIMAT0000689 | MIRT044200 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-302d-3p | MIMAT0000718 | NA | hsa-miR-302d | 19229866 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20969773 | Moreover, a slight upregulation of the oncogene c-Myc, along with an undetectable level of breast tumor-related gene Bag-1 and TRPS-1, was observed in BME65Cs cells while these genes are all highly expressed in MCF-7 |
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