HCSGD entry for TRAF3

1. General information

Official gene symbolTRAF3
Entrez ID7187
Gene full nameTNF receptor-associated factor 3
Other gene symbolsCAP-1 CAP1 CD40bp CRAF1 IIAE5 LAP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001817Regulation of cytokine productionIEA ISSbiological_process
GO:0002224Toll-like receptor signaling pathwayIEA ISS TASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004842Ubiquitin-protein ligase activityIEA TASmolecular_function
GO:0004871Signal transducer activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005768EndosomeIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006915Apoptotic processIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008063Toll signaling pathwayIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0009898Cytoplasmic side of plasma membraneIEA ISScellular_component
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0030162Regulation of proteolysisIEA IMPbiological_process
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0031996Thioesterase bindingIPImolecular_function
GO:0032088Negative regulation of NF-kappaB transcription factor activityIEA IMPbiological_process
GO:0032480Negative regulation of type I interferon productionTASbiological_process
GO:0032648Regulation of interferon-beta productionIEA ISSbiological_process
GO:0033209Tumor necrosis factor-mediated signaling pathwayIEA IMPbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0035631CD40 receptor complexIEA ISScellular_component
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0042981Regulation of apoptotic processIEAbiological_process
GO:0045087Innate immune responseIEA TASbiological_process
GO:0050688Regulation of defense response to virusIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00670995020.96677320770.21511887941.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1229387697
GSE13712_SHEARUp0.5419896903
GSE13712_STATICUp0.4323296377
GSE19018Down-0.1040693946
GSE19899_A1Up0.5036796078
GSE19899_A2Up1.6255714585
PubMed_21979375_A1Up1.5593647055
PubMed_21979375_A2Up1.0425016675
GSE35957Down-0.1259143868
GSE36640Down-0.0031329854
GSE54402Up0.6934431177
GSE9593Up0.2923282269
GSE43922Up0.6995016250
GSE24585Down-0.4935147543
GSE37065Up0.2688456130
GSE28863_A1Up0.3783987422
GSE28863_A2Up0.1251837063
GSE28863_A3Down-0.3020368574
GSE28863_A4Down-0.0139964004
GSE48662Down-0.0160180423

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT028936MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.