HCSGD entry for HSP90B1

1. General information

Official gene symbolHSP90B1
Entrez ID7184
Gene full nameheat shock protein 90kDa beta (Grp94), member 1
Other gene symbolsECGP GP96 GRP94 TRA1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIDAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0003723RNA bindingIDAmolecular_function
GO:0005509Calcium ion bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005783Endoplasmic reticulumIDA IEA TAScellular_component
GO:0005788Endoplasmic reticulum lumenIDA TAScellular_component
GO:0005789Endoplasmic reticulum membraneIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006457Protein foldingIEAbiological_process
GO:0006950Response to stressIEAbiological_process
GO:0006987Activation of signaling protein activity involved in unfolded protein responseTASbiological_process
GO:0015031Protein transportNASbiological_process
GO:0019903Protein phosphatase bindingIDAmolecular_function
GO:0030433ER-associated ubiquitin-dependent protein catabolic processIMPbiological_process
GO:0030496MidbodyIDAcellular_component
GO:0030968Endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0031247Actin rod assemblyIDAbiological_process
GO:0042470MelanosomeIEAcellular_component
GO:0043066Negative regulation of apoptotic processIMP TASbiological_process
GO:0043666Regulation of phosphoprotein phosphatase activityIDAbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046790Virion bindingIPImolecular_function
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050750Low-density lipoprotein particle receptor bindingIDAmolecular_function
GO:0051082Unfolded protein bindingIEAmolecular_function
GO:0051208Sequestering of calcium ionNASbiological_process
GO:0071318Cellular response to ATPIDAbiological_process
GO:0071682Endocytic vesicle lumenTAScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.57775207250.07302092630.99999024730.5094046647

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2859732228
GSE13712_SHEARUp0.1626458490
GSE13712_STATICUp0.0773359340
GSE19018Up0.5837994385
GSE19899_A1Down-0.6431536361
GSE19899_A2Down-0.6992502510
PubMed_21979375_A1Down-0.6325984312
PubMed_21979375_A2Down-2.4984212228
GSE35957Up0.0349066827
GSE36640Up0.0081480982
GSE54402Down-0.0177498193
GSE9593Down-0.1406630108
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.0443824667

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

2-ChlorodideoxyadenosineDB02103 EXPT00881
1-Methoxy-2-(2-Methoxyethoxy)EthaneDB02935 EXPT02086
N-Ethyl-5'-Carboxamido AdenosineDB03719 EXPT02324
RadicicolDB03758 EXPT02763
METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATEDB08464 -
2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATEDB08465 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-15a-5pMIMAT0000068MIRT003874MicroarrayFunctional MTI (Weak)18362358
hsa-miR-192-5pMIMAT0000222MIRT004158MicroarrayFunctional MTI (Weak)16822819
hsa-miR-16-5pMIMAT0000069MIRT004368MicroarrayFunctional MTI (Weak)18362358
hsa-miR-223-3pMIMAT0000280MIRT007086Luciferase reporter assayFunctional MTI23208072
hsa-miR-335-5pMIMAT0000765MIRT017651MicroarrayFunctional MTI (Weak)18185580
hsa-miR-130b-3pMIMAT0000691MIRT020159SequencingFunctional MTI (Weak)20371350
hsa-miR-1MIMAT0000416MIRT023707ProteomicsFunctional MTI (Weak)18668040
hsa-miR-148a-3pMIMAT0000243MIRT025974SequencingFunctional MTI (Weak)20371350
hsa-miR-484MIMAT0002174MIRT041729CLASHFunctional MTI (Weak)23622248
hsa-miR-128-3pMIMAT0000424MIRT045853CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049100CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-15a-5pMIMAT0000068NAhsa-miR-15a18362358
hsa-miR-16-5pMIMAT0000069NAhsa-miR-1618362358
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26515130The UPR resulted in upregulation of ER chaperones including BIP/Grp78, Grp94 and led to an activation of IRE1alpha as evidenced by spliced XBP1 mRNA with IRE1alpha-induced JNK phosphorylation
23466301In particular, the expression levels of 9 genes, HSP90B1, EID1, ATP2B4, DDAH1, PRNP, RAB1A, PGS5, TM4SF1 and SSR3, gradually increased during senescence
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