HCSGD entry for NR2C2

1. General information

Official gene symbolNR2C2
Entrez ID7182
Gene full namenuclear receptor subfamily 2, group C, member 2
Other gene symbolsTAK1 TR2R1 TR4 hTAK1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003677DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0003713Transcription coactivator activityTASmolecular_function
GO:0004872Receptor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedTASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0021549Cerebellum developmentIEAbiological_process
GO:0030154Cell differentiationIEAbiological_process
GO:0040019Positive regulation of embryonic developmentIEAbiological_process
GO:0043565Sequence-specific DNA bindingIDA IEAmolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046982Protein heterodimerization activityIDAmolecular_function
GO:0048520Positive regulation of behaviorIEAbiological_process
GO:0051321Meiotic cell cycleIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.39913799250.18867579120.99999024730.8418790847

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1416289522
GSE13712_SHEARUp0.3544484649
GSE13712_STATICUp0.2346700355
GSE19018Up0.1273486491
GSE19899_A1Down-0.4512598229
GSE19899_A2Down-0.5217730629
PubMed_21979375_A1Down-0.7190351110
PubMed_21979375_A2Down-0.1916250518
GSE35957Up0.1062478278
GSE36640Down-0.3653537636
GSE54402Down-0.0613012440
GSE9593Down-0.1466978450
GSE43922Down-0.4183612252
GSE24585Up0.2890316814
GSE37065Up0.1523672847
GSE28863_A1Up0.6144125007
GSE28863_A2Up0.5014036344
GSE28863_A3Up0.0734476927
GSE28863_A4Down-0.3094488190
GSE48662Up0.3358433835

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT030801MicroarrayFunctional MTI (Weak)18591254
hsa-miR-615-3pMIMAT0003283MIRT039640CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.