HCSGD entry for TPM4
1. General information
| Official gene symbol | TPM4 |
|---|---|
| Entrez ID | 7171 |
| Gene full name | tropomyosin 4 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001725 | Stress fiber | IDA | cellular_component |
| GO:0002102 | Podosome | IEA | cellular_component |
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | NAS | molecular_function |
| GO:0005604 | Basement membrane | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005856 | Cytoskeleton | TAS | cellular_component |
| GO:0005862 | Muscle thin filament tropomyosin | TAS | cellular_component |
| GO:0006928 | Cellular component movement | TAS | biological_process |
| GO:0006936 | Muscle contraction | TAS | biological_process |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0008307 | Structural constituent of muscle | TAS | molecular_function |
| GO:0030049 | Muscle filament sliding | TAS | biological_process |
| GO:0030863 | Cortical cytoskeleton | IEA | cellular_component |
| GO:0031941 | Filamentous actin | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9733227461 | 0.0186219862 | 0.9999902473 | 0.2674027823 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4234833936 |
| GSE13712_SHEAR | Down | -0.0293485876 |
| GSE13712_STATIC | Down | -0.0391815242 |
| GSE19018 | Down | -0.4776673816 |
| GSE19899_A1 | Down | -0.7954077679 |
| GSE19899_A2 | Down | -0.3409742610 |
| PubMed_21979375_A1 | Down | -0.9058949930 |
| PubMed_21979375_A2 | Down | -0.2116762138 |
| GSE35957 | Up | 0.2615273851 |
| GSE36640 | Down | -0.3128523796 |
| GSE54402 | Down | -0.0198851209 |
| GSE9593 | Up | 0.4267447624 |
| GSE43922 | Down | -0.2903196574 |
| GSE24585 | Down | -0.3146219891 |
| GSE37065 | Down | -0.1669081722 |
| GSE28863_A1 | Down | -0.2541675324 |
| GSE28863_A2 | Down | -0.0735668125 |
| GSE28863_A3 | Up | 0.1661190930 |
| GSE28863_A4 | Up | 0.0204983148 |
| GSE48662 | Down | -0.2940654294 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT002782 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-1 | MIMAT0000416 | MIRT002782 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT002782 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024410 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026576 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-940 | MIMAT0004983 | MIRT036591 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045744 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-28-5p | MIMAT0000085 | MIRT049990 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052131 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
