HCSGD entry for C2
1. General information
| Official gene symbol | C2 |
|---|---|
| Entrez ID | 717 |
| Gene full name | complement component 2 |
| Other gene symbols | CO2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004252 | Serine-type endopeptidase activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006956 | Complement activation | TAS | biological_process |
| GO:0006958 | Complement activation, classical pathway | IEA | biological_process |
| GO:0030449 | Regulation of complement activation | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2551345086 | 0.8625917746 | 0.9466414094 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0595468303 |
| GSE13712_SHEAR | Down | -0.0867269041 |
| GSE13712_STATIC | Down | -0.1212471130 |
| GSE19018 | Up | 0.0394311166 |
| GSE19899_A1 | Down | -0.1008957896 |
| GSE19899_A2 | Up | 0.1542607433 |
| PubMed_21979375_A1 | Down | -0.0371121350 |
| PubMed_21979375_A2 | Up | 0.0302680687 |
| GSE35957 | Down | -0.0443625096 |
| GSE36640 | Up | 0.1278945116 |
| GSE54402 | Up | 0.0698649629 |
| GSE9593 | Up | 0.1407479449 |
| GSE43922 | Up | 0.0097268977 |
| GSE24585 | Up | 0.3760848274 |
| GSE37065 | Up | 0.3979687005 |
| GSE28863_A1 | Up | 0.0599497749 |
| GSE28863_A2 | Up | 0.8689960582 |
| GSE28863_A3 | Down | -0.3844691982 |
| GSE28863_A4 | Up | 0.0823679806 |
| GSE48662 | Up | 0.1981580377 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017726 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-142-3p | MIMAT0000434 | MIRT021561 | Microarray | Functional MTI (Weak) | 17612493 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 11 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27651846 | Cells were seeded into 24-well plates with hydrogen peroxide added to cell medium and incubated at 37 degrees C + 5% CO2 for a 90-minute period [at 0, 300, 400 and 800 micromolar (MCM) hydrogen peroxide] |
| 26636143 | For correcting alterations in aged epidermis, chemical peelings (fruit acids, beta-hydroxy acid, trichloroacetic acid, phenolic compounds), non-ablative (IPL, PDL, Nd:YAG) as well as ablative (CO2, Erbium-YAG) light-assisted methods are used |
| 26092041 | Although enhanced carbon fixation by forest trees may contribute significantly to mitigating an increase in atmospheric carbon dioxide (CO2), capacities for this vary greatly among different tree species and locations |
| 26092041 | This study compared reactions in the foliage of a deciduous and a coniferous tree species (important central European trees, beech and spruce) to an elevated supply of CO2 and evaluated the importance of the soil type and increased nitrogen deposition on foliar nutrient concentrations and cellular stress reactions |
| 26092041 | During a period of 4 years, beech (represented by trees from four different regions) and spruce saplings (eight regions), planted together on either acidic or calcareous forest soil in the experimental model ecosystem chambers, were exposed to single and combined treatments consisting of elevated carbon dioxide (+CO2, 590 versus 374 muL L(-1)) and elevated wet nitrogen deposition (+ND, 50 versus 5 kg ha(-1) a(-1)) |
| 26092041 | Leaf size and foliage mass of spruce were increased by +CO2 on both soil types, but those of beech by +ND on the calcareous soil only |
| 26092041 | Although the species elemental concentrations differed in their response to CO2 fertilization, the +CO2 treatment effect was weakened by an acceleration of cell senescence in both species, as shown by a decrease in photosynthetic pigment and nitrogen concentration, discolouration and stress symptoms at the cell level; the latter were stronger in beech than spruce |
| 26092041 | Hence, young trees belonging to a species with different ecological niches can show contrasting responses in their foliage size, but similar responses at the cell level, upon exposure to elevated levels of CO2 |
| 23471026 | METHODS: Primary HCECs were isolated from donor corneal rings and cultivated at 37 degrees C in 5% CO2 and 95% humidified air |
| 20675298 | Here we attempt to avoid aneuploidy and improve cell quality by expanding human cardiac stem cells in physiological low-oxygen (5% O(2)) conditions, rather than in traditional culture in a general CO(2) incubator (20% O(2)) |
| 17669741 | At light saturation, net CO(2) uptake and water-use efficiency were reduced by heavy metal contamination, whereas the CO(2) concentration in the leaf intercellular air space was increased |
| 17189826 | CO(2) changes the biochemistry of peroxynitrite basically in two ways: (i) nitrating species is the CO(3)(-) / ()NO(2) radical pair, and (ii) peroxynitrite diffusion distance is significantly reduced |
| 17189826 | Our results show that at low cell density and in the presence of CO(2) peroxynitrite induced the oxidation of surface thiols, the formation of 3-nitrotyrosine and DMPO-RBC adducts, and the down-regulation of glycophorins A and C (biomarkers of senescence) |
| 17189826 | Without CO(2) peroxynitrite also induced the oxidation of hemoglobin and glutathione, the accumulation of lactate, a decrease in ATP, the clustering of band 3, the externalization of phosphatidylserine, and the activation of caspases 8 and 3 (biomarkers of apoptosis) |
| 15932239 | These include engineering problems (excess biomass and problems with CO(2) removal, optimization of operating conditions, clogging and channeling of the reactor), unbalanced beer flavor (altered cell physiology, cell aging), and unrealized cost advantages (carrier price, complex and unstable operation) |
| 1991578 | It is the most heavily used anion transport system in the body because it is responsible for CO2 exchange in all tissues and organs and for acid-base balance |
| 1859086 | It is responsible for CO2 exchange in all tissues and organs |
| 6388355 | The effect of insulin on glucose utilization in erythroblast and reticulocyte preparations was negligible, as assessed by CO2 and lactate production |
Entries Per Page
Displaying Page of
