HCSGD entry for TOP2A
1. General information
| Official gene symbol | TOP2A |
|---|---|
| Entrez ID | 7153 |
| Gene full name | topoisomerase (DNA) II alpha 170kDa |
| Other gene symbols | TOP2 TP2A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000228 | Nuclear chromosome | IDA | cellular_component |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000287 | Magnesium ion binding | IDA IEA | molecular_function |
| GO:0000712 | Resolution of meiotic recombination intermediates | IBA | biological_process |
| GO:0000793 | Condensed chromosome | IEA | cellular_component |
| GO:0000795 | Synaptonemal complex | IBA | cellular_component |
| GO:0000819 | Sister chromatid segregation | IBA | biological_process |
| GO:0003677 | DNA binding | IDA IEA | molecular_function |
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0003918 | DNA topoisomerase type II (ATP-hydrolyzing) activity | IDA IEA | molecular_function |
| GO:0005080 | Protein kinase C binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | IDA TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA IEA | cellular_component |
| GO:0005814 | Centriole | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0006260 | DNA replication | NAS | biological_process |
| GO:0006261 | DNA-dependent DNA replication | IBA | biological_process |
| GO:0006265 | DNA topological change | IBA IDA IEA | biological_process |
| GO:0006266 | DNA ligation | IDA | biological_process |
| GO:0006281 | DNA repair | NAS | biological_process |
| GO:0006312 | Mitotic recombination | IBA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0007059 | Chromosome segregation | IEA IMP | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0008094 | DNA-dependent ATPase activity | IDA | molecular_function |
| GO:0008144 | Drug binding | IDA | molecular_function |
| GO:0008301 | DNA binding, bending | IDA IEA | molecular_function |
| GO:0009295 | Nucleoid | IBA | cellular_component |
| GO:0009330 | DNA topoisomerase complex (ATP-hydrolyzing) | IDA | cellular_component |
| GO:0019035 | Viral integration complex | NAS | cellular_component |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030261 | Chromosome condensation | IEA | biological_process |
| GO:0030263 | Apoptotic chromosome condensation | IDA | biological_process |
| GO:0040016 | Embryonic cleavage | IEA | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0042826 | Histone deacetylase binding | IPI | molecular_function |
| GO:0043065 | Positive regulation of apoptotic process | IDA | biological_process |
| GO:0043130 | Ubiquitin binding | IMP | molecular_function |
| GO:0043234 | Protein complex | IPI | cellular_component |
| GO:0045070 | Positive regulation of viral genome replication | IMP | biological_process |
| GO:0045870 | Positive regulation of single stranded viral RNA replication via double stranded DNA intermediate | IMP | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IPI | molecular_function |
| GO:0048015 | Phosphatidylinositol-mediated signaling | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7435575776 | 0.0000069374 | 0.9999902473 | 0.0069833333 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -2.8812490607 |
| GSE13712_SHEAR | Down | -0.6846079703 |
| GSE13712_STATIC | Down | -0.7662775657 |
| GSE19018 | Up | 0.2866641535 |
| GSE19899_A1 | Down | -2.6498799246 |
| GSE19899_A2 | Down | -3.6109235104 |
| PubMed_21979375_A1 | Down | -3.5613265521 |
| PubMed_21979375_A2 | Down | -4.7971811745 |
| GSE35957 | Down | -4.0494547062 |
| GSE36640 | Down | -3.2977227158 |
| GSE54402 | Down | -1.3940260741 |
| GSE9593 | Down | -1.7308183503 |
| GSE43922 | Down | -3.5409490157 |
| GSE24585 | Up | 0.0769849527 |
| GSE37065 | Down | -1.3669539874 |
| GSE28863_A1 | Down | -0.2306434787 |
| GSE28863_A2 | Up | 1.9368874059 |
| GSE28863_A3 | Down | -0.3837670121 |
| GSE28863_A4 | Up | 0.4953428919 |
| GSE48662 | Down | -2.5541446202 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016473 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030914 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036474 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-708-5p | MIMAT0004926 | MIRT037756 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045191 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT047766 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26952515 | Gastrointestinal stromal tumors TOP2A, and hTERT telomerase subunit mRNA levels to determine proliferation activity and a potential for aggressive biological behavior |
| 26952515 | The aim of the present study was to investigate Ki-67, TPX2, TOP2A and hTERT mRNA expression levels in specimens from patients with GISTs to define relationships between proliferation activity and biological potential and progression of the disease |
| 26952515 | We measured Ki-67, TPX2, TOP2A and hTERT mRNA levels using quantitative real-time reverse transcription PCR (RQ RT PCR) |
| 26952515 | The highest Ki-67, TPX2, TOP2A and hTERT mRNA expression levels were found in the highly proliferative BLs (18 specimens), in comparison with GISTs (137 specimens) and LMSs (9 specimens) |
| 26952515 | Proliferation markers of Ki-67, TPX2, TOP2A and hTERT are suitable markers for detection the proliferation activity and telomerase activity of these tumors |
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