HCSGD entry for TNFRSF1B

1. General information

Official gene symbolTNFRSF1B
Entrez ID7133
Gene full nametumor necrosis factor receptor superfamily, member 1B
Other gene symbolsCD120b TBPII TNF-R-II TNF-R75 TNFBR TNFR1B TNFR2 TNFR80 p75 p75TNFR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005031Tumor necrosis factor-activated receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0008630Intrinsic apoptotic signaling pathway in response to DNA damageIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043196VaricosityIEAcellular_component
GO:0045121Membrane raftIDAcellular_component
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050728Negative regulation of inflammatory responseIEAbiological_process
GO:0050779RNA destabilizationIEAbiological_process
GO:0051044Positive regulation of membrane protein ectodomain proteolysisIMPbiological_process
GO:0071222Cellular response to lipopolysaccharideIMPbiological_process
GO:0071363Cellular response to growth factor stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06903311800.09756543440.56237099970.5963817464

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1605599200
GSE13712_SHEARDown-1.9736259576
GSE13712_STATICDown-1.7178879022
GSE19018Down-0.1133009842
GSE19899_A1Up0.0537374709
GSE19899_A2Up0.9839893783
PubMed_21979375_A1Up0.2688105803
PubMed_21979375_A2Up0.5024418288
GSE35957Down-0.9296405316
GSE36640Down-1.0273316668
GSE54402Up2.1233333906
GSE9593Up0.1453779278
GSE43922Up0.0515251137
GSE24585Down-0.0277057143
GSE37065Up0.2589401871
GSE28863_A1Up0.2095510543
GSE28863_A2Up0.5115918139
GSE28863_A3Up0.1479305490
GSE28863_A4Down-0.0020391179
GSE48662Down-0.1322093293

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

EtanerceptDB00005 BTD00052 | BIOD00052

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19342460Unexpectedly, these changes were independent of changes in proliferation rate within the hyperplastic tissue, suggesting that endogenous SST controls GHRH-induced adenoma formation primarily via modulation of apoptotic and/or cellular senescence pathways, consistent with the predicted function of some of the most differentially expressed genes (Casp1, MAP2K1, TNFR2) identified by membrane arrays and confirmed by quantitative real-time RT-PCR
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