HCSGD entry for CLDN5
1. General information
| Official gene symbol | CLDN5 |
|---|---|
| Entrez ID | 7122 |
| Gene full name | claudin 5 |
| Other gene symbols | AWAL BEC1 CPETRL1 TMVCF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005198 | Structural molecule activity | IEA | molecular_function |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0005911 | Cell-cell junction | IDA | cellular_component |
| GO:0005923 | Tight junction | ISS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016338 | Calcium-independent cell-cell adhesion | ISS | biological_process |
| GO:0033270 | Paranode region of axon | IEA | cellular_component |
| GO:0042552 | Myelination | IEA | biological_process |
| GO:0042802 | Identical protein binding | ISS | molecular_function |
| GO:0043220 | Schmidt-Lanterman incisure | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0840614566 | 0.6608682915 | 0.6099046780 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | 0.0000000000 |
| GSE13712_SHEAR | Down | -0.5244499884 |
| GSE13712_STATIC | Down | -0.7108136105 |
| GSE19018 | Up | 0.1396391137 |
| GSE19899_A1 | Up | 0.2396853649 |
| GSE19899_A2 | Up | 2.4855642881 |
| PubMed_21979375_A1 | Up | 0.2356684387 |
| PubMed_21979375_A2 | Up | 0.0075072298 |
| GSE35957 | Up | 0.2799854287 |
| GSE36640 | Down | -0.1031627074 |
| GSE54402 | Up | 0.4974853979 |
| GSE9593 | Up | 0.0111543739 |
| GSE43922 | Up | 0.0837675112 |
| GSE24585 | Down | -0.0049560026 |
| GSE37065 | Down | -0.0466533227 |
| GSE28863_A1 | Down | -0.4033807249 |
| GSE28863_A2 | Down | -0.2651390437 |
| GSE28863_A3 | Up | 0.3935851227 |
| GSE28863_A4 | Up | 0.3374341357 |
| GSE48662 | Up | 0.0624355666 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-128-3p | MIMAT0000424 | MIRT021935 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24576879 | Western blot analysis showed that the expression level of myosin light chain, claudin-5, and VE-cadherin significantly reduced under pressure elevation in control cells but not in senescent cells |
| 22929066 | RESULTS: The barrier function of monolayers comprising of senescent cells was compromised and coincided with a change in the distribution of junction proteins and a down-regulation of occludin and claudin-5 expression |
| 22929066 | Furthermore, a decreased expression of occludin and claudin-5 was observed in co-cultures of non-senescent and senescent cells, not only between senescent cells but also along the entire periphery of non-senescent cells lining a senescent cell |
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